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Wnt-7a Is Upregulated by Norethisterone in Human Endometrial Epithelial Cells: A Possible Mechanism by Which Progestogens Reduce the Risk of Estrogen-Induced Endometrial Neoplasia

Wnt-7a Is Upregulated by Norethisterone in Human Endometrial Epithelial Cells: A Possible Mechanism by Which Progestogens Reduce the Risk of Estrogen-Induced Endometrial Neoplasia

M K Oehler, I Z MacKenzie, D Wallwiener, R Bicknell, M C P Rees

Cancer Lett. 2002 Dec 1;186(1):75-81.

PMID: 12183078

Abstract:

Progestogens are added to oestrogen in hormone replacement therapy regimens to reduce the risk of endometrial cancer. We have performed in vitro studies analysing gene expression of isolated normal endometrial epithelia cells (NEE) treated with estradiol and the progestogen norethisterone acetate (NETA). We report here for the first time upregulation of the Wnt-7a gene by NETA in estrogen treated NEE. Wnt genes are a large family of developmental genes associated with cellular responses such as oncogenesis. We therefore suggest that upregulation of Wnt-7a may be associated with the antineoplastic effects of progestogens on the endometrium.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248719	WNT-7A human			Price

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