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Wogonoside Inhibits Tumor Growth and Metastasis in Endometrial Cancer via ER stress-Hippo Signaling Axis

Wogonoside Inhibits Tumor Growth and Metastasis in Endometrial Cancer via ER stress-Hippo Signaling Axis

Shaorong Chen, Zhuna Wu, Yumin Ke, Pingping Shu, Caihong Chen, Ruying Lin, Qirong Shi

Acta Biochim Biophys Sin (Shanghai). 2019 Nov 18;51(11):1096-1105.

PMID: 31696210

Abstract:

Wogonoside, a bioactive flavonoid component derived from Scutellaria baicalensis Georgi, has been reported to inhibit tumor growth in mice bearing various types of cancer cells such as breast cancer, lung cancer, and leukemia cells. However, whether wogonoside could inhibit tumor growth of endometrial cancer has not been elucidated. In this study, we explored the function of wogonoside on tumor growth and the underlying mechanism on endometrial cancer. Firstly, we investigated the effect of wogonoside on endometrial cancer cells and found that wogonoside could significantly decrease cell proliferation and metastasis. Mechanistically, wogonoside could aggravate the extent of ER stress and upregulate the phosphorylation level of Mammalian Ste20-like kinase 1, leading to the activation of the Hippo signaling pathway. Taken together, in vitro and in vivo data demonstrated that wogonoside could be a potent inducer of ER stress and could be further developed into a promising therapy for endometrial cancer.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP51059440	Wogonoside		51059-44-0	Price

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