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Xanthine oxidase functionalized Ta 2 O 5 nanostructures as a novel scaffold for highly sensitive SPR based fiber optic xanthine sensor

Xanthine oxidase functionalized Ta 2 O 5 nanostructures as a novel scaffold for highly sensitive SPR based fiber optic xanthine sensor

Ravi Kant, Rana Tabassum, Banshi D Gupta

Biosens Bioelectron. 2018 Jan 15;99:637-645.

PMID: 28841534

Abstract:

Fabrication and characterization of a surface plasmon resonance based fiber optic xanthine sensor using entrapment of xanthine oxidase (XO) enzyme in several nanostructures of tantalum (v) oxide (Ta2O5) have been reported. Chemical route was adopted for synthesizing Ta2O5 nanoparticles, nanorods, nanotubes and nanowires while Ta2O5 nanofibers were prepared by electrospinning technique. The synthesized Ta2O5 nanostructures were characterized by photoluminescence, scanning electron microscopy, UV-Visible spectra and X-ray diffraction pattern. The probes were fabricated by coating an unclad core of the fiber with silver layer followed by the deposition of XO entrapped Ta2O5 nanostructures. The crux of sensing mechanism relies on the modification of dielectric function of sensing layer upon exposure to xanthine solution of diverse concentrations, reflected in terms of shift in resonance wavelength. The sensing probe coated with XO entrapped Ta2O5 nanofibers has been turned out to possess maximum sensitivity amongst the synthesized nanostructures. The probe was optimized in terms of pH of the sample and the concentration of XO entrapped in Ta2O5 nanofibers. The optimized sensing probe possesses a remarkably good sensitivity of 26.2nm/µM in addition to linear range from 0 to 3µM with an invincible LOD value of 0.0127µM together with a response time of 1min. Furthermore, probe selectivity with real sample analysis ensure the usage of the sensor for practical scenario. The results reported open a novel perspective towards a sensitive, rapid, reliable and selective detection of xanthine.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1314610	Tantalum(V) oxide		1314-61-0	Price

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