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Xanthones Isolated From the Pericarp of Mangosteen Inhibit Neurotransmitter Receptors Expressed in Xenopus Oocytes

Xanthones Isolated From the Pericarp of Mangosteen Inhibit Neurotransmitter Receptors Expressed in Xenopus Oocytes

Pathama Leewanich, Sunit Suksamram

J Med Assoc Thai. 2015 Nov;98 Suppl 10:S118-23.

PMID: 27276843

Abstract:

Objective:
This study aimed to evaluate inhibitory effects of 7 xanthones and 3 extracts obtained from the pericarp of mangosteen on serotonin (5-HT), N-methyl-D-aspartate (NMDA) and glycine receptors expressed in Xenopus oocytes.
Material and method:
Xenopus oocytes were injected with RNA of either 5-HT NMDA or glycine receptor and inhibitory effects of the xanthones and extracts were investigated using the two-electrode voltage clamp technique.
Results:
Xanthones from the pericarp of mangosteen affected 5-HT NMDA and glycine receptor functions with different degree of inhibition. Alpha-mangostin, garcinone-D and 9-hydroxycalaba xanthone inhibited 5-H T-induced currents by more than 80%. Gamma-mangostin and garcinone-E did by more than 50%, but not more than 80%. Garcinone-C and garcinone- D inhibited glutamate-induced currents by more than 80%. The alcohol extract did by more than 50%, but not more than 80%. Alpha-mangostin, garcinone-C, garcinone-D, non-tannin extract and the alcohol extract inhibited glycine-induced currents between 50-70%, neither compounds inhibited the currents up to 80%.
Conclusion:
These results suggest that each xanthone derivatives has different selectivity to different types of neurotransmitter receptors.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP107390089	Garcinone D		107390-08-9	Price

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