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Zero Balance Ultrafiltration Using Dialysate During Nationwide Bicarbonate Shortage: A Retrospective Analysis

Zero Balance Ultrafiltration Using Dialysate During Nationwide Bicarbonate Shortage: A Retrospective Analysis

Ryan Mullane, Lance Fristoe, Nicholas W Markin, Tara R Brakke, Helen Mari Merritt-Genore, Aleem Siddique, Clifford D Miles, Troy J Plumb

J Cardiothorac Surg. 2019 Sep 10;14(1):163.

PMID: 31500645

Abstract:

Background:
Zero balance ultrafiltration (Z-BUF) utilizing injectable 8.4% sodium bicarbonate is utilized to treat hyperkalemia and metabolic acidosis associated with cardiopulmonary bypass (CPB). The nationwide shortage of injectable 8.4% sodium bicarbonate in 2017 created a predicament for the care of cardiac surgery patients. Given the uncertainty of availability of sodium bicarbonate solutions, our center pro-actively sought a solution to the sodium bicarbonate shortage by performing Z-BUF with dialysate (Z-BUF-D) replacement fluid for patients undergoing cardiopulmonary bypass.
Methods:
Single-center, retrospective observational evaluation of the first 46 patients at an academic medical center who underwent Z-BUF using dialysate over a period of 150 days with comparison of these findings to a historical group of 39 patients who underwent Z-BUF with sodium chloride (Z-BUF-S) over the preceding 150 days. The primary outcome was the change in whole blood potassium levels pre- and post-Z-BUF-D. Secondary outcomes included changes in pre- and post-Z-BUF-D serum bicarbonate levels and the amount of serum bicarbonate used in each Z-BUF cohort (Z-BUF-D and Z-BUF-S).
Results:
Z-BUF-D and Z-BUF-S both significantly reduced potassium levels during CPB. However, Z-BUF-D resulted in a significantly decreased need for supplemental 8.4% sodium bicarbonate administration during CPB (52 mEq ± 48 vs. 159 mEq ± 85, P < 0.01). There were no complications directly attributed to the Z-BUF procedure.
Conclusion:
Z-BUF with dialysate appears to be analternative to Z-BUF with sodium chloride with marked lower utilization of intravenous sodium bicarbonate.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1262333254	(Z)-N′-Methylmeloxicam		1262333-25-4	Price

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