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Zinc Oxide and Copper Nanoparticles Addition in Universal Adhesive Systems Improve Interface Stability on Caries-Affected Dentin

Zinc Oxide and Copper Nanoparticles Addition in Universal Adhesive Systems Improve Interface Stability on Caries-Affected Dentin

Mario Felipe Gutiérrez, Jorge Bermudez, Andrés Dávila-Sánchez, Luisa F Alegría-Acevedo, Luján Méndez-Bauer, Marcela Hernández, Jessica Astorga, Alessandra Reis, Alessandro D Loguercio, Paulo V Farago, Eduardo Fernández

J Mech Behav Biomed Mater. 2019 Dec;100:103366.

PMID: 31422314

Abstract:

This study evaluated the MMP inhibition of the zinc oxide and copper nanoparticles (ZnO/CuNp), and the effects of their addition into adhesives on antimicrobial activity (AMA), ultimate tensile strength (UTS), in vitro degree of conversion (in vitro-DC), as well as, resin-dentin bond strength (μTBS), nanoleakage (NL) and in situ-DC on caries-affected dentin. Anti-MMP activity was evaluated for several MMPs. ZnO/CuNp (0% [control]; 5/0.1 and 5/0.2 wt%) were added into Prime&Bond Active (PBA) and Ambar Universal (AMB). The AMA was evaluated against Streptococcus mutans. UTS were tested after 24 h and 28d. After induced caries, adhesives and composite were applied to flat dentin surfaces, and specimens were sectioned to obtain resin-dentin sticks. μTBS, NL, in vitro-DC and in situ-DC were evaluated after 24 h. ANOVA and Tukey's test were applied (α = 0.05). ZnO/CuNp demonstrated anti-MMP activity (p < 0.05). The addition of ZnO/CuNp increased AMA and UTS (AMB; p < 0.05). UTS for PBA, in vitro-DC, in situ-DC and μTBS for both adhesives were maintained with ZnO/CuNp (p > 0.05). However, lower NL was observed for ZnO/CuNp groups (p < 0.05). The addition of ZnO/CuNp in adhesives may be an alternative to provide antimicrobial, anti-MMP activities and improves the integrity of the hybrid layer on caries-affected dentin.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4241273	MMP Control-5			Price

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