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Zonisamide Decreases Ethanol Intake in Rats and Mice

Zonisamide Decreases Ethanol Intake in Rats and Mice

Clifford M Knapp, Melissa Mercado, Tara Lynn Markley, Steven Crosby, Domenic A Ciraulo, Conan Kornetsky

Pharmacol Biochem Behav. 2007 May;87(1):65-72.

PMID: 17482246

Abstract:

Several anticonvulsant agents, including topiramate and valproate, have been found to reduce alcohol consumption in rodent models of drinking. The question of whether the novel anticonvulsant agent, zonisamide, shares similar actions in either mice or rats was investigated in the present experiments. In an initial experiment, the consumption of a 10% ethanol-5% sucrose solution, available for one hour, by Wistar rats treated with lactose, topiramate, or zonisamide was determined. In a second experiment, the intake of a 10% ethanol/water solution, accessible for two hours, by C57BL/B6N mice treated with either zonisamide or vehicle was assessed. In the rat, 50 mg/kg (PO) doses of either topiramate or zonisamide produced significant, but moderate decreases in ethanol/sucrose intake. The administration of a 50 mg/kg (IP) dose of zonisamide to mice resulted in a marked lowering in ethanol consumption. These results provide evidence that zonisamide administration will decrease ethanol consumption by both mice and rats in limited access models of drinking, and might, like topiramate, be useful as a medication for alcoholism.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP68291974-A	Zonisamide solution		68291-97-4	Price

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