CAS 78-96-6 1-Amino-2-propanol - Analytical Products / Alfa Chemistry

CAT	APS78966
CAS	78-96-6
Structure
Synonyms	(2-Hydroxy-2-methylethyl)amine, (±)-1-Amino-2-propanol, 1-Methyl-2-aminoethanol, 2-Hydroxypropanamine,1-Amino-2-propanol, (RS)-1-amino-2-propanol, α-Aminoisopropyl alcohol, 2-Amino-1-methylethanol, MIPA, (RS)-1-Amino-2-hydroxypropane, Threamine, 2-Hydroxypropylamine, dl-1-Amino-2-propanol, DL-1-Amino-2-propanol, β-Aminoisopropanol, Isopropanolamine, Monoisopropanolamine, 1-Amino-2-hydroxypropane, 2-Hydroxy-1-propylamine, 2-Hydroxy-1-propanamine, 1-Aminoisopropanol, NSC 3188
IUPAC Name	1-aminopropan-2-ol
Molecular Weight	75.11
Molecular Formula	C3H9NO
Canonical SMILES	CC(O)CN
InChI	InChI=1S/C3H9NO/c1-3(5)2-4/h3,5H,2,4H2,1H3

Accurate Mass	75.0684
Format	Neat
Shipping	Room Temperature
Storage Conditions	+20°C
Subcategory	Hydrocarbons and petrochemicals

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Case Study

1-Amino-2-propanol as a Precursor for Bio-Renewable Ionic Liquids in the Green Extraction of Natural Antioxidants

Yu, Mingyuan, et al. Journal of Molecular Liquids 322 (2021): 115014.

1-Amino-2-propanol (PA) has emerged as a key building block for synthesizing bio-renewable ionic liquids (PA-ILs), offering a safer and more sustainable alternative to traditional organic solvents in natural product extraction. In a recent study, a series of PA-based ionic liquids were synthesized via equimolar neutralization of PA with various carboxylic acids to yield colorless viscous liquids with >99% yield. These PA-ILs were then applied to extract antioxidant compounds from Artemisia argyi (Mugwort), demonstrating remarkable extraction selectivity.
Among ten synthesized PA-ILs, PA/mandelic acid, PA/EDTA, and PA/lactic acid exhibited the highest efficiency in extracting polyphenols (120.34 mg/g), flavones (128.87 mg/g), and polysaccharides (43.62 mg/g), respectively. Notably, the antioxidant activity assessed via DPPH radical scavenging confirmed that flavones were the dominant contributors and that PA-ILs outperformed conventional solvents. Reversed-phase HPLC revealed a higher polarity profile of the ILs extract, indicating improved solubilization of glycosidic compounds.
FT-IR analysis uncovered a complex hydrogen-bonding network within the PA-ILs, which is hypothesized to enhance extraction performance. Furthermore, cytotoxicity studies using HaCaT and Caco-2 cell lines showed lower toxicity for PA-ILs compared to pure PA, supporting their biocompatibility.
These findings underscore the value of 1-amino-2-propanol as a green chemical platform for preparing task-specific ionic liquids aimed at efficient, safe, and selective extraction of plant-derived bioactives.

1-Amino-2-propanol in CO₂ Capture: Addressing Oxidative Degradation with Chelating Agent Blends

Liu, Q., Yin, Y., Gao, H., Liu, L., Xu, S., Sema, T., ... & Liang, Z. (2025). Chemical Engineering Science, 122051.

1-Amino-2-propanol (1AP) is a promising alternative solvent for post-combustion CO₂ capture due to its low volatility and favorable absorption kinetics. However, its oxidative degradation, particularly in the presence of transition metal ions such as Fe²⁺/Fe³⁺, remains a significant barrier to its long-term industrial use. A recent study explored the use of chelating agents and free radical scavengers to mitigate this degradation, thereby enhancing the operational efficiency and economic viability of 1AP-based CO₂ capture systems.
The study introduced a quantifiable metric, the inhibition factor, to assess the effectiveness of various inhibitors. Notably, the use of chelating agents such as DTPA and DTPMP led to substantial reductions in amine loss-from 47.0% (iron-catalyzed degradation) to 6.8% and 10.8%, respectively-outperforming even the baseline scenario without iron. This remarkable inhibition is attributed not only to the chelation of iron ions, which suppresses catalytic degradation pathways, but also to the potential scavenging of free radicals.
Furthermore, blending inhibitors yielded synergistic effects, increasing the inhibition factor to 9.4 while reducing the required dosage. This highlights a strategic approach to extend 1AP solvent life and minimize degradation byproducts, such as NH₃ and heat-stable salts.
These findings demonstrate the value of 1-amino-2-propanol in CO₂ capture applications and the pivotal role of tailored inhibitor systems in overcoming its oxidative instability.