ABT-089 dihydrochloride

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For Research Use Only | Not For Clinical Use
Molecular Weight265.18
Description≥98% (HPLC)
SolubilityH2O: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Size5MG, 25MG
Storage Conditions2-8°C

1ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine Dihydrochloride]: II. A Novel Cholinergic Channel Modulator With Effects on Cognitive Performance in Rats and Monkeys

M W Decker, A W Bannon, P Curzon, K L Gunther, J D Brioni, M W Holladay, N H Lin, Y Li, J F Daanen, J J Buccafusco, M A Prendergast, W J Jackson, S P Arneric

J Pharmacol Exp Ther. 1997 Oct;283(1):247-58.

PMID: 9336330

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1ABT-089: Pharmacological Properties of a Neuronal Nicotinic Acetylcholine Receptor Agonist for the Potential Treatment of Cognitive Disorders

Lynne E Rueter, David J Anderson, Clark A Briggs, Diana L Donnelly-Roberts, Gary A Gintant, Murali Gopalakrishnan, Nan-Horng Lin, Mark A Osinski, Glenn A Reinhart, Michael J Buckley, Ruth L Martin, Jeffrey S McDermott, etc.

CNS Drug Rev. Summer 2004;10(2):167-82.

PMID: 15179445

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1Central Nicotinic Receptor Agonists ABT-418, ABT-089, and (-)-Nicotine Reduce Distractibility in Adult Monkeys

M A Prendergast, W J Jackson, A V Terry Jr, M W Decker, S P Arneric, J J Buccafusco

Psychopharmacology (Berl). 1998 Mar;136(1):50-8.

PMID: 9537682

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1Glutamatergic Contributions to Nicotinic Acetylcholine Receptor Agonist-Evoked Cholinergic Transients in the Prefrontal Cortex

Vinay Parikh, Kingson Man, Michael W Decker, Martin Sarter

J Neurosci. 2008 Apr 2;28(14):3769-80.

PMID: 18385335

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1Pharmacokinetic Modeling and [¹²³]5-IA-85380 Single Photon Emission Computed Tomography Imaging in Baboons: Optimization of Dosing Regimen for ABT-089

Chih-Liang Chin, Robert A Carr, Daniel A Llano, Olivier Barret, Hongyu Xu, Jeffrey Batis, Andrei O Koren, John P Seibyl, Kennan C Marsh, Gilles Tamagnan, Michael W Decker, Mark Day, Gerard B Fox

J Pharmacol Exp Ther. 2011 Mar;336(3):716-23.

PMID: 21172907

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