Cevimeline hydrochloride hemihydrate

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For Research Use Only | Not For Clinical Use
Molecular Weight199.31 (anhydrous free base basis)
Description≥95% (HPLC, NMR)
SolubilityH2O: ≥25 mg/mL
Assay≥95% (HPLC, NMR)
Colorwhite to tan
Size5MG, 25MG
Storage Conditions−20°C

1(+/-)-cis-2-methylspiro[1,3-oxathiolane-5,3'-quinuclidine] Hydrochloride, Hemihydrate (SNI-2011, Cevimeline Hydrochloride) Induces Saliva and Tear Secretions in Rats and Mice: The Role of Muscarinic Acetylcholine Receptors

Y Iga, H Arisawa, N Ogane, Y Saito, T Tomizuka, Y Nakagawa-Yagi, H Masunaga, H Yasuda, N Miyata

Jpn J Pharmacol. 1998 Nov;78(3):373-80.

PMID: 9869272

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1Long-lasting Salivation Induced by a Novel Muscarinic Receptor Agonist SNI-2011 in Rats and Dogs

H Masunaga, H Ogawa, Y Uematsu, T Tomizuka, H Yasuda, Y Takeshita

Eur J Pharmacol. 1997 Nov 19;339(1):1-9.

PMID: 9450610

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1Salivary Secretion and Histopathological Effects After Single Administration of the Muscarinic Agonist SNI-2011 in MRL/lpr Mice

Y Iwabuchi, M Katagiri, T Masuhara

Arch Int Pharmacodyn Ther. Nov-Dec 1994;328(3):315-25.

PMID: 7542865

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1Structural Characterization of Cevimeline and Its Trans-Impurity by Single Crystal XRD

Dmitrijs Stepanovs, Zenta Tetere, Irisa Rāviņa, Viktors Kumpiņš, Daina Zicāne, Ērika Bizdēna, Jānis Bogans, Irina Novosjolova, Agnese Grigaloviča, Remo Merijs Meri, Juris Fotins, Maksims Čerkasovs, Anatoly Mishnev, etc.

J Pharm Biomed Anal. 2016 Jan 25;118:404-409.

PMID: 26609680

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