CAS 85721-33-1 Ciprofloxacin - Analytical Products / Alfa Chemistry

CAT	APS85721331
CAS	85721-33-1
Structure
MDL Number	MFCD00185755
Synonyms	Ciflafin, 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxo-3-quinoline carboxylic acid, Ciproxim, Euciprin, Ciprofloxacillin, Cyclofloxacin, Oftacifox, Procip, Urociproxin, Cinthocip 500, Cipronex, Ciprofloxacin, Pulmaquin, Ciprobay 100, Ciprodac, Novidate, 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid, Cipro IV, Ciprolet,3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-, Quinox XR, OTO 201, Profloxacin, Ciprine, Ciprox, Ciprofloxacine, Otiprio, 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, Ciproval, Catex, Cunesin, Ciproxina, Ciprovet, Lipoquin, Cipropol, AuriPro, Cipromed, Infu-luxacin, BAY-q 3939, Ciprolet DS
Molecular Weight	331.34
Molecular Formula	C17H18FN3O3
InChI	InChI=1S/C17H18FN3O3/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24/h7-10,19H,1-6H2,(H,23,24)
InChI Key	MYSWGUAQZAJSOK-UHFFFAOYSA-N
REAXYS Number	3568352

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CAT	Size	Shipping	Storage Conditions	Description	Price
APS85721331-1	100MG			Subcategory: Pharmaceutical and veterinary compounds and metabolites	Inquiry
APS85721331-2	20MG	Room Temperature	2-8°C Fridge/Coldroom	API Family: Matrix - API Family See respective official monograph(s); Product Type: API; Subcategory: European Pharmacopoeia (Ph. Eur.)	Inquiry
APS85721331-3	20MG	Room Temperature	2-8°C Fridge/Coldroom	API Family: Matrix - API Family See respective official monograph(s); Product Type: API; Subcategory: International Pharmacopoeia	Inquiry

Case Study

Ciprofloxacin Used for Fluorescence-Based Detection via CuNCs@His/MOF-5 Nanocomposite Sensor

Kheirkhahnia, Shaghayegh, and Susan Sadeghi. Journal of Photochemistry and Photobiology A: Chemistry 462 (2025): 116259.

Ciprofloxacin has been employed as a target analyte in the development of a novel fluorescent sensing system based on histidine-protected copper nanoclusters (CuNCs@His) embedded within a zinc-based metal-organic framework (MOF-5). The resulting CuNCs@His/MOF-5 nanocomposite acts as a "turn-on" fluorescent probe, enabling the sensitive and selective quantification of ciprofloxacin in aqueous media.
The synthesized hybrid nanomaterial displayed strong fluorescence emission at 438 nm under 345 nm excitation. The sensing strategy relies on a significant enhancement in fluorescence intensity upon interaction with ciprofloxacin, forming the basis for a calibration curve. Under optimized conditions, a linear detection range of 0.01-0.20 µg mL⁻¹ was established with an excellent limit of detection (LOD) of 0.01 µg mL⁻¹ and a relative standard deviation of 2.6%.
Quantitative fluorometric measurements were performed by incubating 1 mL of CuNCs@His/MOF-5 suspension with varying concentrations of ciprofloxacin in phosphate buffer solution. After a 15-minute incubation, fluorescence intensities were measured, and the difference between sample (F) and blank (F₀) signals (ΔF) was used to construct a sensitive calibration curve.
This study demonstrates ciprofloxacin's utility in fluorescence-based biosensing systems, highlighting its role in the validation of highly responsive nanocomposite platforms for environmental or pharmaceutical monitoring applications.

Ciprofloxacin Used for the Preparation of Multifunctional Ciprofloxacin-Loaded Cu₂O Nanoparticles with Therapeutic Potential

Laib, Ibtissam, Abderrhmane Bouafia, Salah Eddine Laouini, Mahmood MS Abdullah, Hamad A. Al-Lohedan, Ethar M. AlEssa, and Johar Amin Ahmed Abdullah. Journal of Crystal Growth (2025): 128074.

Ciprofloxacin has been effectively utilized for the synthesis of ciprofloxacin-loaded copper oxide nanoparticles (CIP@Cu₂O NPs), enabling the development of multifunctional nanomaterials with enhanced biomedical applications. This green and cost-effective formulation demonstrates remarkable therapeutic efficacy, exhibiting potent antidiabetic, antioxidant, anti-inflammatory, and antibacterial activities, especially against drug-resistant bacterial strains.
In the synthesis process, ciprofloxacin was initially dissolved in deionized water (0.5 mg/mL) to obtain a homogeneous solution. Simultaneously, Cu₂O nanoparticles were ultrasonically dispersed (5 mg/mL) at 42 °C for 30 minutes to prevent agglomeration. The well-dispersed Cu₂O NPs were gradually introduced into the ciprofloxacin solution under continuous stirring for an additional 30 minutes, promoting effective surface adsorption of the drug onto the nanoparticles. The resulting CIP@Cu₂O colloid was stored at 4 °C in sterile conditions to ensure stability.
The synthesized CIP@Cu₂O NPs serve as an advanced drug delivery system, enhancing the bioavailability and functionality of ciprofloxacin. The integration of a known antibiotic with copper oxide nanoparticles not only improves antimicrobial activity but also adds synergistic bioactivities beneficial for chronic disease treatment.
This study underscores the innovative application of ciprofloxacin in nanomedicine, facilitating the creation of multifunctional therapeutic agents targeting both infectious and metabolic disorders.

Ciprofloxacin Used for Electrochemical Sensing Evaluation via MXene-Derived Titanate Nanoribbon Electrodes

Chakravorty, A., Das, S., Mini, A. A., Awasthi, S., Pandey, S. K., & Raghavan, V. (2025). Materials Advances, 6(6), 2090-2109.

Ciprofloxacin, a widely used fluoroquinolone antibiotic, has emerged as a model analyte in the development of high-performance electrochemical sensors. In recent research, ciprofloxacin was employed to assess the sensing capability of novel MXene-derived potassium titanate nanoribbons (KTNR) used as electrode materials. The electrochemical behavior of ciprofloxacin was systematically evaluated using cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV) in a 0.1 M phosphate buffer solution (pH 8).
The KTNR-modified electrodes demonstrated outstanding sensitivity, with a linear detection range spanning from 0.6 μM to 147.2 μM. The sensor achieved detection limits as low as 0.07 μM (CV), 0.0608 μM (DPV), and 0.0264 μM (SWV), positioning it as a promising tool for trace-level detection. Remarkably, ciprofloxacin was selectively detected in diverse real-world matrices, including environmental (marine and river water, soil, fertilizer) and food samples (milk, honey, eggs), as well as simulated body fluids.
A robust sample preparation protocol ensured analytical reproducibility, involving homogenization, ultrasonication, filtration (0.22 μm), and 10-fold dilution prior to ciprofloxacin spiking at 15 μM.
This study underscores the utility of ciprofloxacin as a benchmark analyte for validating advanced nanostructured electrodes, facilitating the advancement of next-generation pharmaceutical and environmental monitoring platforms.