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For research use only. Not intended for any clinical use
MDL NumberMFCD18785641
Molecular Weight431.53
Description≥95% (HPLC)
Size5MG, 25MG
Assay≥95% (HPLC)
SolubilityDMSO: ≥10 mg/mL
Storage Conditions2-8°C

1CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells

Karima Bettayeb, Dianne Baunbæk, Claire Delehouze, Nadège Loaëc, Alison J Hole, Sonja Baumli, Jane A Endicott, Setha Douc-Rasy, Jean Bénard, Nassima Oumata, Hervé Galons, Laurent Meijer

Genes Cancer. 2010 Apr;1(4):369-80.

PMID: 21779453

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1Comparing Effects of CDK Inhibition and E2F1/2 Ablation on Neuronal Cell Death Pathways in Vitro and After Traumatic Brain Injury

Taryn G Aubrecht, Alan I Faden, Boris Sabirzhanov, Ethan P Glaser, Brian A Roelofs, Brian M Polster, Oleg Makarevich, Bogdan A Stoica

Cell Death Dis. 2018 Nov 6;9(11):1121.

PMID: 30401820

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1CR8, a Potent and Selective, Roscovitine-Derived Inhibitor of Cyclin-Dependent Kinases

K Bettayeb, N Oumata, A Echalier, Y Ferandin, J A Endicott, H Galons, L Meijer

Oncogene. 2008 Oct 2;27(44):5797-807.

PMID: 18574471

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1Crystal Structure of SPSB2 in Complex With a Rational Designed RGD-containing Cyclic Peptide Inhibitor of SPSB2-iNOS Interaction

Tingting You, Yuhui Wang, Kefa Li, Danting Zhang, Huan Wei, Yanhong Luo, Hua Li, Yongzhi Lu, Xunchen Su, Zhihe Kuang

Biochem Biophys Res Commun. 2017 Jul 29;489(3):346-352.

PMID: 28549582

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1Pharmacokinetics and Biodistribution of the Cyclin-Dependent Kinase Inhibitor -CR8- In Mice

Hatem Sallam, Ibrahim El-Serafi, Laurent Meijer, Moustapha Hassan

BMC Pharmacol Toxicol. 2013 Sep 30;14:50.

PMID: 24079553

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