Dextran sulfate sodium salt

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CAT

LS74844

Bidirectional Neural Interaction Between Central Dopaminergic and Gut Lesions in Parkinson's Disease Models

Pablo Garrido-Gil, Ana I Rodriguez-Perez, Antonio Dominguez-Meijide, Maria J Guerra, Jose L Labandeira-Garcia

Mol Neurobiol. 2018 Sep;55(9):7297-7316.

PMID: 29404956

Dihydrotanshinone I, a Natural Product, Ameliorates DSS-induced Experimental Ulcerative Colitis in Mice

Yanling Guo, Xiaxia Wu, Qin Wu, Yuanfu Lu, Jingshan Shi, Xiuping Chen

Toxicol Appl Pharmacol. 2018 Apr 1;344:35-45.

PMID: 29496522

Secoisolariciresinol Diglucoside Suppresses Dextran Sulfate Sodium Salt-Induced Colitis Through Inhibiting NLRP1 Inflammasome

Zhen Wang, Tuo Chen, Chunrong Yang, Ting Bao, Xiaoli Yang, Fang He, Yanting Zhang, Lili Zhu, Hongbo Chen, Shikuo Rong, Shaoqi Yang

Int Immunopharmacol. 2020 Jan;78:105931.

PMID: 31812068

Unconjugated Bilirubin Alleviates Experimental Ulcerative Colitis by Regulating Intestinal Barrier Function and Immune Inflammation

Jia-Dong Zheng, Yan He, Heng-Yuan Yu, Yuan-Li Liu, Yi-Xuan Ge, Xue-Ting Li, Xue Li, Yan Wang, Meng-Ru Guo, Yi-Lin Qu, Xiao-Fa Qin, Ming-Shan Jiang, Xiu-Hong Wang

World J Gastroenterol. 2019 Apr 21;25(15):1865-1878.

PMID: 31057300

Yogurt Starter Cultures of Streptococcus Thermophilus and Lactobacillus Bulgaricus Ameliorate Symptoms and Modulate the Immune Response in a Mouse Model of Dextran Sulfate Sodium-Induced Colitis

E Wasilewska, D Zlotkowska, B Wroblewska

J Dairy Sci. 2019 Jan;102(1):37-53.

PMID: 30343915

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CAT	Size	Description	Price
LS74844-1	5G, 25G, 100G	Mr ~40,000	Inquiry
LS74844-2	5G, 25G, 100G	Mw 7,000-20,000	Inquiry
LS74844-3	5G, 25G, 100G		Inquiry
LS74844-4	5G, 25G, 100G		Inquiry

Case Study

Dextran Sulfate Sodium Used for the Selective Depression of Dolomite in Apatite Flotation Applications

Ma, Rui, et al. Minerals Engineering 227 (2025): 109291.

Dextran sulfate sodium (DSS), a biodegradable and eco-friendly polymer surfactant, has been employed as a novel depressant for the selective separation of apatite (Apa) from dolomite (Dol) in direct flotation processes. This separation is traditionally difficult due to the similar surface properties of the two minerals and the poor selectivity of conventional fatty acid collectors like sodium oleate (NaOL).
Experimental flotation tests using DSS demonstrated highly selective depression of Dol without significantly affecting Apa recovery. Wettability and zeta potential measurements revealed preferential DSS adsorption on Dol surfaces, rendering them hydrophilic and impeding collector adsorption. X-ray photoelectron spectroscopy (XPS) analysis confirmed the strong chelation of DSS's -OSO₃²⁻ groups with Ca²⁺ and Mg²⁺ on the Dol surface. In contrast, DSS showed weak, easily displaced physiosorption on Apa, allowing NaOL to effectively promote flotation.
Density Functional Theory (DFT) calculations further elucidated the selective interaction mechanism. The -OSO₃²⁻ moieties formed ionic bonds with Mg 3s and Ca 4s orbitals on Dol surfaces, while steric hindrance and atomic density differences limited DSS binding on Apa.
These findings position dextran sulfate sodium as a promising green depressant in phosphate beneficiation. Its compatibility with NaOL and strong selectivity offer a simplified alternative to reverse flotation methods, lowering reagent usage, reducing environmental impact, and improving cost-efficiency in mineral processing operations.

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