CAS 106-24-1 Geraniol - Analytical Products / Alfa Chemistry

CAT	APS106241A
CAS	106-24-1
Structure
MDL Number	MFCD00002917
Synonyms	Geraniol, Geraniol 60, (E)-3,7-Dimethyl-2,6-octadienol, NSC 9279, β-Geraniol, Geraniol 980, (E)-Nerol, trans-Geraniol,2,6-Octadien-1-ol, 3,7-dimethyl-, (2E)-, 3,7-Dimethyl-trans-2,6-octadien-1-ol, trans-3,7-Dimethyl-2,6-octadien-1-ol, (2E)-3,7-Dimethyl-2,6-octadien-1-ol, TT 4228, (E)-3,7-Dimethyl-2,6-octadien-1-ol, 2,6-Octadien-1-ol, 3,7-dimethyl-, (E)- (8CI), Geraniol BJ, TT 4302, (E)-Geraniol, trans-1-Hydroxy-3,7-dimethyl-2,6-octadiene, Geranyl alcohol, Lemonol, MosquitoSafe
IUPAC Name	(2E)-3,7-dimethylocta-2,6-dien-1-ol
Molecular Weight	154.25
Molecular Formula	C10H18O
EC Number	203-377-1
Canonical SMILES	CC(=CCC\C(=C\CO)\C)C
InChI	InChI=1S/C10H18O/c1-9(2)5-4-6-10(3)7-8-11/h5,7,11H,4,6,8H2,1-3H3/b10-7+
InChI Key	GLZPCOQZEFWAFX-JXMROGBWSA-N
REAXYS Number	1722456

Description	analytical standard
Density	0.879 g/mL at 20 °C (lit.)
Accurate Mass	154.1358
Assay	≥98.5% (GC)
BP	229-230 °C (lit.)
Form	neat; gas chromatography (GC): suitable
Format	Neat
Grade	analytical standard
Linear Formula	(CH3)2C=CHCH2CH2C(CH3)=CHCH2OH
Refractive Index	n20/D 1.474 (lit.); n20/D 1.478
Shipping	Room Temperature
Size	1ML, 5ML
Storage Conditions	-18°C
Subcategory	Pharmaceutical and veterinary compounds and metabolites, EU Methods
Vapor Density	5.31 (vs air)

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Case Study

Geraniol Used for the Preparation of Electrospun Antifungal Nanofibers via β-Cyclodextrin Inclusion Complexation

Gupta, Payal, et al. Journal of Drug Delivery Science and Technology 91 (2024): 105186.

In this study, geraniol was used to prepare antifungal nanofibers through a structured fabrication process involving β-cyclodextrin complexation and electrospinning. The first step involved forming an inclusion complex by stirring geraniol with β-cyclodextrin in a 1:1 molar ratio for 24 hours at room temperature, enabling improved solubility and stability of geraniol.
Separately, a polymer matrix was prepared by dissolving 10% (w/v) polyvinyl alcohol (PVA) and 1% (w/v) acacia gum (AG) in distilled water, then mixing them in a 5:1 ratio. This PVA/AG blend served as the carrier for nanofiber formation. To fabricate geraniol-loaded nanofibers (GR-NF), 200 mg of the prepared inclusion complex was added to the polymer solution.
Electrospinning was conducted using a 10 mL syringe filled with the polymer-drug mixture. The electrospinning parameters were finely tuned: a voltage of 23 kV, a tip-to-collector distance of 18 cm, and a flow rate of 0.5 mL/h. This process yielded smooth nanofibers with consistent morphology. Control nanofibers (NF0), without geraniol, were fabricated under identical conditions for comparison.
The resulting GR-NFs demonstrated sustained drug release and excellent antifungal performance, with significant biofilm inhibition and eradication. This method underscores the effective use of geraniol for preparing electrospun nanofibers through a reproducible and scalable experimental protocol.

Geraniol Used for the Preparation of Photodynamically Active GR@MOF-545 for Antibacterial Food Packaging

Bai, Haoran, et al. Chemical Engineering Journal 498 (2024): 155503.

Geraniol, a bioactive monoterpenoid, was successfully utilized in the preparation of GR@MOF-545, a multifunctional antibacterial material designed for active food packaging. In this study, a porphyrin-based metal-organic framework (MOF-545) was synthesized via solvothermal reaction using zirconium oxychloride and tetrakis(4-carboxyphenyl)porphyrin (H₂TCPP) as precursors. Post-synthesis, geraniol was incorporated into MOF-545 through a solvent-assisted loading method to yield GR@MOF-545.
The GR@MOF-545 hybrid exhibits dual antibacterial functionality through synergistic chemical and photodynamic mechanisms. Upon light exposure, the porphyrinic core generates reactive oxygen species (ROS), while geraniol provides sustained antibacterial action. The resulting material demonstrated >99% antibacterial efficiency against both E. coli and S. aureus under visible light.
To fabricate an active packaging film, GR@MOF-545 was embedded into a composite matrix of polyvinyl alcohol (PVA) and carboxymethyl chitosan (CMCS), producing PC/GR@MOF-545. This film exhibited remarkable preservation effects on cherry tomatoes, maintaining physical, chemical, and nutritional parameters over a 12-day storage period under light conditions.
This case highlights how geraniol is used for the preparation of photodynamically enhanced GR@MOF-545, offering a novel solution for food preservation by combining essential oil efficacy with MOF-driven ROS generation in an integrated antibacterial packaging strategy.

Geraniol Used for the Preparation of Sodium Caseinate-Based Antimicrobial Nanobiocomposite Films for Active Food Packaging

Chakraborty, Priyanka, Subrota Hati, and Birendra Kumar Mishra. Food Bioscience 61 (2024): 104665.

Geraniol (GR), a natural essential oil with known antimicrobial properties, has been effectively utilized for the preparation of sodium caseinate (SC)-based nanobiocomposite films intended for sustainable food packaging. In this study, GR was incorporated alone or in combination with halloysite nanoclay (HS) into SC films using a modified solution casting method. The resulting films-formulated as SC/GR, SC/HS, and SC/HS/GR-demonstrated enhanced barrier, mechanical, and antimicrobial properties.
Compared to pure SC films, the addition of GR and HS significantly reduced moisture content (from 13.47% to 7.85%), water solubility, and water vapor transmission rates, while improving surface hydrophobicity and mechanical strength. Specifically, Young's modulus increased from 69.85 MPa to 110.12 MPa with increasing GR and HS content. Fourier-transform infrared spectroscopy and X-ray diffraction revealed semi-crystalline structures with increased β-sheet content, indicating structural reinforcement of the protein matrix.
Importantly, the GR-enriched films exhibited strong antimicrobial efficacy, inhibiting Escherichia coli and Bacillus cereus growth. When applied as coatings on capsicum fruits, the SC/HS/GR films effectively reduced weight loss and maintained firmness and color, thereby extending shelf life.
This case underscores that geraniol is used for the preparation of protein-based biocomposite films with enhanced physicochemical and antimicrobial functionality, supporting its role as a green additive in active food packaging systems.