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For Research Use Only | Not For Clinical Use
Molecular Weight325.34
Description≥98% (HPLC), solid
SolubilityDMSO: >10 mg/mL; H2O: <2 mg/mL
Assay≥98% (HPLC)
Size1MG, 5MG
Storage Conditions−20°C

1(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors With Broad Antiproliferative Activity Against Tumor Cells

Chih Y Ho, Donald W Ludovici, Umar S M Maharoof, Jay Mei, Jan L Sechler, Robert W Tuman, Eric D Strobel, Laura Andraka, Hwa-Kwo Yen, Gregory Leo, Jian Li, Harold Almond, Hong Lu, Ann DeVine, Rose M Tominovich, etc.

J Med Chem. 2005 Dec 29;48(26):8163-73.

PMID: 16366598

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1A High-Content Small Molecule Screen Identifies Sensitivity of Glioblastoma Stem Cells to Inhibition of Polo-Like Kinase 1

Davide Danovi, Amos Folarin, Sabine Gogolok, Christine Ender, Ahmed M O Elbatsh, Pär G Engström, Stefan H Stricker, Sladjana Gagrica, Ana Georgian, Ding Yu, Kin Pong U, Kevin J Harvey, Patrizia Ferretti, etc.

PLoS One. 2013 Oct 30;8(10):e77053.

PMID: 24204733

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1N-glucuronidation of the Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitor 6,7-(dimethoxy-2,4-dihydroindeno[1,2-C]pyrazol-3-yl)-(3-fluoro-phenyl)-amine by Human UDP-glucuronosyltransferases

Z Yan, G W Caldwell, D Gauthier, G C Leo, J Mei, C Y Ho, W J Jones, J A Masucci, R W Tuman, R A Galemmo Jr, D L Johnson

Drug Metab Dispos. 2006 May;34(5):748-55.

PMID: 16455802

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1Oral Coadministration of β-glucuronidase to Increase Exposure of Extensively Glucuronidated Drugs That Undergo Enterohepatic Recirculation

Gary Eichenbaum, C-P Hsu, Vangala Subrahmanyam, Jing Chen, Jan Scicinski, Robert A Galemmo Jr, Robert W Tuman, Dana L Johnson

J Pharm Sci. 2012 Jul;101(7):2545-56.

PMID: 22473491

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1PDGFR and IGF-1R Inhibitors Induce a G2/M Arrest and Subsequent Cell Death in Human Glioblastoma Cell Lines

Estefania Carrasco-Garcia, Isabel Martinez-Lacaci, Leticia Mayor-López, Elena Tristante, Mar Carballo-Santana, Pilar García-Morales, Maria Paz Ventero Martin, Maria Fuentes-Baile, Álvaro Rodriguez-Lescure, etc.

Cells. 2018 Sep 6;7(9):131.

PMID: 30200644

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