NS8593

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For Research Use Only | Not For Clinical Use
CATIAR4249505
Molecular Weight263.34
DescriptionAn aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels in a Ca2+-dependent manner.
SolubilityDMSO: 100 mg/mL
Assay≥98% (HPLC)
Colorwhite
Formpowder; protect from light
Size10MG
Storage Conditions+2C to +8C

1Arrhythmia Development During Inhibition of Small-Conductance Calcium-Activated Potassium Channels in Acute Myocardial Infarction in a Porcine Model

Anniek F Lubberding, Stefan M Sattler, Morten Grunnet, Ulrik S Sørensen, Jacob Tfelt-Hansen, Thomas Jespersen

Europace. 2019 Oct 1;21(10):1584-1593.

PMID: 31408093

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1Impact of Ca 2+-Sensitive Potassium Channels in Levosimendan-Induced Postconditioning

Martin Stroethoff, Sebastian Bunte, Annika Raupach, Margit van de Snepscheut, Carolin Torregroza, André Heinen, Alexander Mathes, Markus W Hollmann, Ragnar Huhn, Stephan U Sixt

Cardiovasc Drugs Ther. 2019 Oct;33(5):581-588.

PMID: 31705225

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1Natural and Synthetic Modulators of SK (K(ca)2) Potassium Channels Inhibit Magnesium-Dependent Activity of the Kinase-Coupled Cation Channel TRPM7

V Chubanov, M Mederos y Schnitzler, M Meißner, S Schäfer, K Abstiens, T Hofmann, T Gudermann

Br J Pharmacol. 2012 Jun;166(4):1357-76.

PMID: 22242975

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1NS8593 inhibits Ca 2+ permeant channels reversing mouse airway smooth muscle contraction

Bei-Bei Liu, Yong-Bo Peng, Wen-Jing Zhang, Xiao-Xue Zhao, Li-Ping Chen, Meng-Su Liu, Ge-Ge Wang, Ya-Jing Liu, Jinhua Shen, Ping Zhao, Lu Xue, Meng-Fei Yu, Weiwei Chen, Li-Qun Ma, Gangjian Qin, Jiapei Dai, etc.

Life Sci. 2019 Dec 1;238:116953.

PMID: 31626793

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1The TRPM7 Channel Kinase Regulates Store-Operated Calcium Entry

Malika Faouzi, Tatiana Kilch, F David Horgen, Andrea Fleig, Reinhold Penner

J Physiol. 2017 May 15;595(10):3165-3180.

PMID: 28130783

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