NSC 663284

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For Research Use Only | Not For Clinical Use
MDL NumberMFCD08276924
Molecular Weight321.76
Description≥98% (HPLC), solid
SolubilityDMSO: ≥10 mg/mL; H2O: insoluble
Assay≥98% (HPLC)
Size5MG, 25MG
Storage Conditions2-8°C

1Discovery and Biological Evaluation of a New Family of Potent Inhibitors of the Dual Specificity Protein Phosphatase Cdc25

J S Lazo, D C Aslan, E C Southwick, K A Cooley, A P Ducruet, B Joo, A Vogt, P Wipf

J Med Chem. 2001 Nov 22;44(24):4042-9.

PMID: 11708908

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1Dual G1 and G2 Phase Inhibition by a Novel, Selective Cdc25 Inhibitor 6-chloro-7-[corrected](2-morpholin-4-ylethylamino)-quinoline-5,8-dione

Lixia Pu, Andrew A Amoscato, Mark E Bier, John S Lazo

J Biol Chem. 2002 Dec 6;277(49):46877-85.

PMID: 12356752

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1Identification of Highly Potent and Selective Cdc25 Protein Phosphatases Inhibitors From Miniaturization Click-Chemistry-Based Combinatorial Libraries

Lanlan Jing, Gaochan Wu, Xia Hao, Fisayo A Olotu, Dongwei Kang, Chin Ho Chen, Kuo-Hsiung Lee, Mahmoud E S Soliman, Xinyong Liu, Yuning Song, Peng Zhan

Eur J Med Chem. 2019 Dec 1;183:111696.

PMID: 31541869

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1NAD(P)H:quinone oxidoreductase-1-dependent and -Independent Cytotoxicity of Potent Quinone Cdc25 Phosphatase Inhibitors

Yusheng Han, Hongmei Shen, Brian I Carr, Peter Wipf, John S Lazo, Su-shu Pan

J Pharmacol Exp Ther. 2004 Apr;309(1):64-70.

PMID: 14718602

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