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For Research Use Only | Not For Clinical Use
Molecular Weight267.26
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Size5MG, 25MG
Storage Conditions−20°C

1A Small-Molecule Inhibitor of UBE2N Induces Neuroblastoma Cell Death via Activation of p53 and JNK Pathways

J Cheng, Y-H Fan, X Xu, H Zhang, J Dou, Y Tang, X Zhong, Y Rojas, Y Yu, Y Zhao, S A Vasudevan, H Zhang, J G Nuchtern, E S Kim, X Chen, F Lu, J Yang

Cell Death Dis. 2014 Feb 20;5(2):e1079.

PMID: 24556694

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1Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting

Curtis D Hodge, Ross A Edwards, Craig J Markin, Darin McDonald, Mary Pulvino, Michael S Y Huen, Jiyong Zhao, Leo Spyracopoulos, Michael J Hendzel, J N Mark Glover

ACS Chem Biol. 2015 Jul 17;10(7):1718-28.

PMID: 25909880

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1Dynamic Regulation of Dynein Localization Revealed by Small Molecule Inhibitors of Ubiquitination Enzymes

Julie K Monda, Iain M Cheeseman

Open Biol. 2018 Sep 26;8(9):180095.

PMID: 30257893

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1Inhibition of Ubiquitin-conjugating Enzyme E2 May Activate the Degradation of Hypoxia-inducible Factors And, Thus, Overcome Cellular Resistance to Radiation in Colorectal Cancer

Navchaa Gombodorj, Takehiko Yokobori, Shinji Yoshiyama, Reika Kawabata-Iwakawa, Susumu Rokudai, Ikuko Horikoshi, Masahiko Nishiyama, Takashi Nakano

Anticancer Res. 2017 May;37(5):2425-2436.

PMID: 28476810

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1UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling

Anushka Dikshit, Yingai J Jin, Simone Degan, Jihwan Hwang, Matthew W Foster, Chuan-Yuan Li, Jennifer Y Zhang

Cancer Res. 2018 Nov 15;78(22):6462-6472.

PMID: 30224375

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