NSC73306

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For Research Use Only | Not For Clinical Use
CATAP79560740
CAS79560-74-0
Molecular Weight326.37
Description≥98% (HPLC)
SolubilityDMSO: 10 mg/mL, clear
Assay≥98% (HPLC)
Color, yellow to light brown
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C

1Evidence for Dual Mode of Action of a Thiosemicarbazone, NSC73306: A Potent Substrate of the Multidrug Resistance Linked ABCG2 Transporter

Chung-Pu Wu, Suneet Shukla, Anna Maria Calcagno, Matthew D Hall, Michael M Gottesman, Suresh V Ambudkar

Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3287-96.

PMID: 18089722

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1Selective Toxicity of NSC73306 in MDR1-positive Cells as a New Strategy to Circumvent Multidrug Resistance in Cancer

Joseph A Ludwig, Gergely Szakács, Scott E Martin, Benjamin F Chu, Carol Cardarelli, Zuben E Sauna, Natasha J Caplen, Henry M Fales, Suresh V Ambudkar, John N Weinstein, Michael M Gottesman

Cancer Res. 2006 May 1;66(9):4808-15.

PMID: 16651436

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1Synthesis and Structure-Activity Evaluation of isatin-β-thiosemicarbazones With Improved Selective Activity Toward Multidrug-Resistant Cells Expressing P-glycoprotein

Matthew D Hall, Kyle R Brimacombe, Matthew S Varonka, Kristen M Pluchino, Julie K Monda, Jiayang Li, Martin J Walsh, Matthew B Boxer, Timothy H Warren, Henry M Fales, Michael M Gottesman

J Med Chem. 2011 Aug 25;54(16):5878-89.

PMID: 21721528

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1Synthesis, Activity, and Pharmacophore Development for Isatin-Beta-Thiosemicarbazones With Selective Activity Toward Multidrug-Resistant Cells

Matthew D Hall, Noeris K Salam, Jennifer L Hellawell, Henry M Fales, Caroline B Kensler, Joseph A Ludwig, Gergely Szakács, David E Hibbs, Michael M Gottesman

J Med Chem. 2009 May 28;52(10):3191-204.

PMID: 19397322

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1Uptake of Compounds That Selectively Kill Multidrug-Resistant Cells: The Copper Transporter SLC31A1 (CTR1) Increases Cellular Accumulation of the Thiosemicarbazone NSC73306

King Leung Fung, Abisola K Tepede, Kristen M Pluchino, Lynn M Pouliot, Jessica N Pixley, Matthew D Hall, Michael M Gottesman

Mol Pharm. 2014 Aug 4;11(8):2692-702.

PMID: 24800945

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