CAS 103-90-2 Paracetamol - Analytical Products / Alfa Chemistry

CAT	APS103902
CAS	103-90-2
Structure
Synonyms	Acetaminophen, Datril, Lonarid, Tylenol, Dolprone, Sara, Tapar, Paraspen, Resfenol, Valadol, p-(Acetylamino)phenol, p-Aceaminophenol, Biocetamol, Salzone, Anhiba, Bickie-mol, 4-Acetaminophenol, Apamide, Vick Pyrena, Cetadol, Citramon P, Naprinol, Paldesic, Tachipirina, Duorol, 4-(Acetylamino)phenol, Napafen, Pamol, Valgesic, Algotropyl, Dymadon, Nebs, Phendon, Acenol, Perfalgan, Ortensan, Disprol, Daphalgan, Parmol, Febrilex, Paramol, Pinex, Doliprane, Paracetamole, Panets, Tabalgin, Endophy, Acamol, N-Acetyl-p-aminophenol, Panadol Extend, Rhodapop NCR, Dirox,Acetamide, N-(4-hydroxyphenyl)-, Panadol Actifast, Gelocatil, Temlo, Exdol, Dafalgan, NSC 3991, Nobedon, 4-(N-Acetylamino)phenol, Eu-Med, Claratal, Captin, Phenaphen, N-Acetyl-4-hydroxyaniline, Tempra, Fendon, Fepanil, Pedric, Multin, p-Acetoaminophen, Anaflon, Pyrinazine, 4-Acetamidophenol, Banesin, Pacemol, Acetanilide, 4'-hydroxy-, Lestemp, NAPAP, Febrilix, Prodafalgan, Alpiny, Panaleve, Gattaphen T, Pinex (pharmaceutical), Paracetamol, Jin Gang, Parelan, Amadil, Panasorb, Pacemo, Ben-u-ron, Lyteca, Tralgon, Crocin, Eneril, Calpol, NAPA, Tempanal, Resprin, Apamid, Acenol (pharmaceutical), p-Acetamidophenol, Clixodyne, Paracetamol DC, Abensanil, N-(4-Hydroxyphenyl)acetamide, 4'-Hydroxyacetanilide, NSC 109028, Alvedon, Liquagesic, Paralen, Dial-a-gesic, APAP, Acetaminofen, 4-Hydroxyacetanilide, Momentum, Febro-Gesic, NAPA (analgesic), Pasolind N, Panodil, p-Hydroxyacetanilide, Homoolan, Panadol, Lyteca Syrup, Korum, N-Acetyl-4-aminophenol, Acetagesic, Febrolin, Hedex, Efferalgan, Puerxitong, Finimal, Acetalgin, Enelfa, Anelix, panadeine, Daga
IUPAC Name	N-(4-hydroxyphenyl)acetamide
Molecular Weight	151.16
Molecular Formula	C8H9NO2
Canonical SMILES	CC(=O)Nc1ccc(O)cc1
InChI	InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

Accurate Mass	151.0633
Format	Neat

* Products or Services Interested: Paracetamol (103-90-2)
* Your question
* Name
* Email
Verification Code

CAT	Size	Shipping	Storage Conditions	Description	Price
APS103902-1	100MG	Room Temperature	2-8°C Fridge/Coldroom	Subcategory: British Pharmacopoeia; API Family: Matrix - API Family See respective official monograph(s); Product Type: API	Inquiry
APS103902-2	250MG	Room Temperature	+20°C	Subcategory: Pharmaceutical and veterinary compounds and metabolites, EU Methods	Inquiry
APS103902-3	50MG	Room Temperature	2-8°C Fridge/Coldroom	Subcategory: European Pharmacopoeia (Ph. Eur.); API Family: Matrix - API Family See respective official monograph(s); Product Type: API	Inquiry
APS103902-4	100MG	Room Temperature	2-8°C Fridge/Coldroom	Subcategory: International Pharmacopoeia; API Family: Matrix - API Family See respective official monograph(s); Product Type: API	Inquiry
APS103902-5	250MG	Room Temperature	+5°C	Subcategory: Analgesics, Mikromol, Impurity standards, API standards; API Family: Matrix - API Family Phenacetin; Paracetamol (Acetaminophen); Product Type: API/ Impurity	Inquiry

Case Study

Paracetamol Used for Investigating Modulation of Neutrophil ROS Activity and Antioxidant Response

Smith, Peter P., et al. Chemico-Biological Interactions 404 (2024): 111283.

Paracetamol, a widely administered analgesic and antipyretic, is increasingly recognized for its immunomodulatory effects beyond cyclooxygenase inhibition. In this study, paracetamol was employed to evaluate its impact on neutrophil-derived reactive oxygen species (ROS), with implications for host immune response modulation. Using ex vivo flow cytometry and in vitro antioxidant assays, the researchers assessed neutrophil function following both oral ingestion and direct exposure to paracetamol.
The results demonstrated that paracetamol significantly reduced ROS production in neutrophils ex vivo shortly after administration. In vitro assays confirmed the antioxidant capacity of paracetamol and its reactive metabolite, N-acetyl-p-benzoquinone imine (NAPQI), both of which directly scavenged ROS. Moreover, paracetamol exposure suppressed the formation of neutrophil extracellular traps (NETs), a key antimicrobial mechanism reliant on ROS generation.
These findings point to a rapid downregulation of neutrophil oxidative burst and NET release in the presence of paracetamol, highlighting its potential to transiently dampen innate immune responses. The implications are particularly relevant for immunocompromised individuals or those receiving vaccines, where neutrophil function is critical.
This case study underscores the utility of paracetamol in dissecting redox-regulated immune functions and warrants further investigation into its broader immunopharmacological profile.

Paracetamol Used for Evaluating Tabletability in Roller Compaction with Commercial Mannitol Grades

Palugan, Luca, et al. Journal of Drug Delivery Science and Technology (2025): 106689.

Paracetamol, a widely used analgesic and antipyretic, serves as a model drug in dry granulation studies due to its poor flowability and compactibility. In this study, paracetamol was utilized to assess the performance of four commercial mannitol grades-powder (PO), spray-dried (XL and EZ), and granular (GR)-in roller compaction dry granulation, a technique increasingly adopted in pharmaceutical manufacturing to improve powder flow and tablet uniformity.
Binary mixtures containing 20-80% paracetamol and each mannitol grade were subjected to roller compaction under varying pressures. The resulting granules were evaluated for particle size distribution, bulk density, flowability, and tabletability. Spray-dried mannitol (XL and EZ) produced granules with excellent flow and allowed for robust tablet formation at 20% paracetamol loading; however, tabletability decreased sharply at higher drug content. Mannitol GR enabled tablet formation only at 20% paracetamol, showing limited application. In contrast, mannitol PO permitted tablet production at up to 80% paracetamol content, albeit requiring high compaction pressures and yielding mechanically weaker tablets.
This study demonstrates that paracetamol is a valuable probe compound for evaluating excipient performance in dry granulation. The data underscore the critical influence of mannitol grade on granule and tablet quality, informing formulation strategies for high-dose, poorly compactible APIs.