CAS 313674-97-4 PD-118057 - Analytical Products / Alfa Chemistry

CAT	AP313674974
CAS	313674-97-4
MDL Number	MFCD08705328
Molecular Weight	386.27
InChI Key	ZCQOSCDABPVAFB-UHFFFAOYSA-N

1

Bisoprolol, Known to Be a Selective β₁-Receptor Antagonist, Differentially but Directly Suppresses I

Edmund Cheung So, Ning-Ping Foo, Shun Yao Ko, Sheng-Nan Wu

Int J Mol Sci. 2019 Feb 2;20(3):657.

PMID: 30717422

1

Investigating the Utility of Adult Zebrafish Ex Vivo Whole Hearts to Pharmacologically Screen hERG Channel Activator Compounds

Christina M Hull, Christine E Genge, Yuki Hobbs, Kaveh Rayani, Eric Lin, Marvin Gunawan, Sanam Shafaattalab, Glen F Tibbits, Tom W Claydon

Am J Physiol Regul Integr Comp Physiol. 2019 Dec 1;317(6):R921-R931.

PMID: 31664867

1

Novel Potent Human Ether-A-Go-Go-Related Gene (hERG) Potassium Channel Enhancers and Their in Vitro Antiarrhythmic Activity

Jun Zhou, Corinne E Augelli-Szafran, Jenifer A Bradley, Xian Chen, Bryan J Koci, Walter A Volberg, Zhuoqian Sun, Jason S Cordes

Mol Pharmacol. 2005 Sep;68(3):876-84.

PMID: 15976038

1

PD-118057 Contacts the Pore Helix of hERG1 Channels to Attenuate Inactivation and Enhance K+ Conductance

Matthew Perry, Frank B Sachse, Jennifer Abbruzzese, Michael C Sanguinetti

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20075-80.

PMID: 19892732

1

Pharmacologic Approach to Defective Protein Trafficking in the E637K-hERG Mutant With PD-118057 and Thapsigargin

Haiyan Mao, Xiaoli Lu, Justin Michael Karush, Xiaoyan Huang, Xi Yang, Yanna Ba, Ying Wang, Ningsheng Liu, Jianqing Zhou, Jiangfang Lian

PLoS One. 2013 Jun 19;8(6):e65481.

PMID: 23840331