PF-04217903

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For Research Use Only | Not For Clinical Use

CAT	AP956906937
CAS	956906-93-7
MDL Number	MFCD17392584
Molecular Weight	468.49
InChI Key	HBEMHKVWZJTVOC-UHFFFAOYSA-N

Description	≥98% (HPLC)
Solubility	DMSO: ≥5 mg/mL (warmed)
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	2-8°C

1Hgf/Met Activation Mediates Resistance to BRAF Inhibition in Murine Anaplastic Thyroid Cancers

Jeffrey A Knauf, Kathleen A Luckett, Kuen-Yuan Chen, Francesca Voza, Nicholas D Socci, Ronald Ghossein, James A Fagin

J Clin Invest. 2018 Aug 31;128(9):4086-4097.

PMID: 29990309

1Insight Into the Key Features for Ligand Binding in Y1230 Mutated c-Met Kinase Domain by Molecular Dynamics Simulations

Libo Yan, Li Zhang, Yanmin Zhang, Xin Qiao, Jing Pan, Haichun Liu, Shuai Lu, Bingren Xiang, Tao Lu, Haoliang Yuan

J Biomol Struct Dyn. 2018 Jun;36(8):2015-2031.

PMID: 28599617

1Sensitivity of Selected Human Tumor Models to PF-04217903, a Novel Selective c-Met Kinase Inhibitor

Helen Y Zou, Qiuhua Li, Joseph H Lee, Maria E Arango, Kristina Burgess, Ming Qiu, Lars D Engstrom, Shinji Yamazaki, Max Parker, Sergei Timofeevski, Jingrong Jean Cui, Michele McTigue, Gerrit Los, Steven L Bender, etc.

Mol Cancer Ther. 2012 Apr;11(4):1036-47.

PMID: 22389468

1The Study of Endogenous Hepatocyte Growth Factor in the Pathogenesis of Intracranial Aneurysms

L-L Yu, Y-J Liu, Z-H Wang, L Shi, L-X Liu

Eur Rev Med Pharmacol Sci. 2017 Feb;21(4):795-803.

PMID: 28272703

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