CAS 2226-71-3 Phosphopantetheine - Analytical Products / Alfa Chemistry

CAT	APB2226713
CAS	2226-71-3
Structure
Molecular Weight	358.35
Molecular Formula	C11H23N2O7PS

What is the molecular weight of Phosphopante- Theine?

The molecular weight of Phosphopante- Theine is 358.35.

What is the molecular formula of Phosphopante- Theine?

The molecular formula of Phosphopante- Theine is C11H23N2O7PS.

Can you provide the CAS number for Phosphopante- Theine?

The CAS number for Phosphopante- Theine is 2226-71-3.

What is the significance of the phosphopante- Theine molecule in biochemistry?

Phosphopante- Theine is a crucial component of coenzyme A, which plays a vital role in various metabolic pathways.

How is phosphopante- Theine synthesized in biological systems?

Phosphopante- Theine is typically synthesized through enzymatic reactions involving panto- Thenic acid and cysteine.

What is the role of phosphopante- Theine in fatty acid biosynthesis?

Phosphopante- Theine serves as a carrier molecule for intermediates during fatty acid biosynthesis, facilitating their transport between different enzymes.

Are there any known therapeutic applications of phosphopante- Theine?

Phosphopante- Theine has shown promise in research for potential therapeutic applications in various metabolic disorders and neurodegenerative diseases.

How does phosphorylation affect the function of phosphopante- Theine?

Phosphorylation of phosphopante- Theine can modulate its activity and interactions with other molecules, influencing its role in cellular processes.

Can phosphopante- Theine be used as a biomarker in diagnostic tests?

While not commonly used as a biomarker, phosphopante- Theine levels may provide valuable information in certain diagnostic tests related to metabolic conditions.

Are there any known interactions or side effects associated with phosphopante- Theine supplementation?

Phosphopante- Theine supplementation is generally considered safe, but interactions with other medications or potential side effects may vary depending on individual health conditions.

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Case Study

4'-Phosphopantetheine (4-PPanSH) as a Biomarker for Coronary Heart Disease and Its Antioxidant Effects on Atherosclerosis

Zhai, Taiyu, et al. Frontiers in Physiology 13 (2022): 989105.

4'-Phosphopantetheine (4-PPanSH) has emerged as a potential biomarker for assessing the severity of coronary heart disease (CHD). This case study highlights the role of 4-PPanSH in CHD and its therapeutic potential in reducing atherosclerosis.
CHD, caused by coronary atherosclerosis, is a leading cause of morbidity and mortality worldwide. The identification of biomarkers for early diagnosis and effective treatment remains a significant challenge. In this study, the plasma metabolite 4-PPanSH was identified using HPLC-MS/MS, and its levels were inversely correlated with the degree of coronary blockage.
Plasma 4-PPanSH levels were analyzed in CHD patients, revealing a decrease in the metabolite as coronary stenosis worsened. In a murine model, 4-PPanSH supplementation reduced atherosclerotic plaque formation and endothelial injury. Additionally, 4-PPanSH inhibited ROS generation and ox-LDL accumulation in vascular endothelial cells.
The findings indicate that 4-PPanSH acts as a potent antioxidant, inhibiting oxidative stress, and may serve as a biomarker for assessing the severity of coronary blockage. Its supplementation in mice demonstrated protective effects against atherosclerosis.

4'-Phosphopantetheine (4'-PP) as a Fusion Tag for Site-Selective Protein Immobilization

Zheng, Yujiao, et al. New Biotechnology 72 (2022): 114-121.

4'-Phosphopantetheine (4'-PP) has been successfully utilized as a novel fusion tag for site-specific protein immobilization, offering precise control over protein orientation and improved catalytic performance in enzymatic reactions.
In Escherichia coli, 4'-PP is covalently attached to acyl carrier protein (ACP), enabling its conversion to an active holo-ACP form. This modification allows 4'-PP to serve as an efficient tag for the site-selective immobilization of proteins. The flexibility of the 4'-PP arm facilitates chemoselective reactions with iodoacetyl groups on solid supports, providing a robust and mild method for protein immobilization.
4'-PP-modified ACP fusions, such as ACP-GFP and ACP-mCherry, were used to investigate the immobilization process. Proteins were covalently attached to resin through the 4'-PP group, with the immobilization process completed in approximately 45 minutes at room temperature. The molecular ratio of co-immobilized proteins could be manipulated by adjusting their concentrations, leading to efficient multi-protein systems.
Compared to traditional thiol-based methods, immobilization via 4'-PP resulted in higher catalytic efficiency (kcat/Km) for enzymes like α-amylase and methyl parathion hydrolase. Notably, α-amylase showed enhanced thermostability when immobilized via holo-ACP, making it more suitable for industrial applications.