R1530

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For Research Use Only | Not For Clinical Use
CATAP882531875
CAS882531-87-5
MDL NumberMFCD23704870
Molecular Weight356.78
InChI KeyUOVCGJXDGOGOCZ-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Color, white to yellow to light brown
Formpowder
Storage Conditions2-8°C

1Discovery of a Highly Potent, Orally Active mitosis/angiogenesis Inhibitor r1530 for the Treatment of Solid Tumors

Jin-Jun Liu, Brian Higgins, Grace Ju, Kenneth Kolinsky, Kin-Chun Luk, Kathryn Packman, Giacomo Pizzolato, Yi Ren, Kshitij Thakkar, Christian Tovar, Zhuming Zhang, Peter M Wovkulich

ACS Med Chem Lett. 2013 Jan 15;4(2):259-63.

PMID: 24900658

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1Evaluation of Protein Kinase Inhibitors With PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer

Amreena Suri, Anders W Bailey, Maurício T Tavares, Hendra Gunosewoyo, Connor P Dyer, Alex T Grupenmacher, David R Piper, Robert A Horton, Tadanori Tomita, Alan P Kozikowski, Saktimayee M Roy, Simone T Sredni

Int J Mol Sci. 2019 Apr 29;20(9):2112.

PMID: 31035676

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1Preclinical Evaluation of the Novel Multi-Targeted Agent R1530

Kenneth Kolinsky, Christian Tovar, Yu-E Zhang, Aruna Railkar, Hong Yang, Daisy Carvajal, Thomas Nevins, Wanping Geng, Michael Linn, Kathryn Packman, Jin-Jun Liu, Zhuming Zhang, Peter Wovkulich, Grace Ju, etc.

Cancer Chemother Pharmacol. 2011 Dec;68(6):1585-94.

PMID: 21553286

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1Small-molecule Inducer of Cancer Cell Polyploidy Promotes Apoptosis or Senescence: Implications for Therapy

Christian Tovar, Brian Higgins, Dayanand Deo, Kenneth Kolinsky, Jin-Jun Liu, David C Heimbrook, Lyubomir T Vassilev

Cell Cycle. 2010 Aug 15;9(16):3364-75.

PMID: 20814247

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1Structural Coincidence of Alpha PDGFR Epitopes Binding to Platelet-Derived Growth factor-AA and a Potent Neutralizing Monoclonal Antibody

J C Yu, D Mahadevan, W J LaRochelle, J H Pierce, M A Heidaran

J Biol Chem. 1994 Apr 8;269(14):10668-74.

PMID: 7511602

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