Ro 61-8048

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For Research Use Only | Not For Clinical Use
MDL NumberMFCD11040807
Molecular Weight421.45
Description≥98% (HPLC)
SolubilityDMSO: ≥15 mg/mL
Assay≥98% (HPLC)
Colorfaintly yellow to yellow
Size5MG, 25MG
Storage Conditions2-8°C

1Biochemistry and Structural Studies of Kynurenine 3-monooxygenase Reveal Allosteric Inhibition by Ro 61-8048

Jingjing Gao, Licheng Yao, Tingting Xia, Xuebin Liao, Deyu Zhu, Ye Xiang

FASEB J. 2018 Apr;32(4):2036-2045.

PMID: 29208702

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1Effects of the Kynurenine 3-hydroxylase Inhibitor Ro 61-8048 After Intrastriatal Injections on the Severity of Dystonia in the Dt Sz Mutant

Melanie Hamann, Svenja E Sander, Angelika Richter

Eur J Pharmacol. 2008 May 31;586(1-3):156-9.

PMID: 18353306

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1Is Ro 61-8048 a Potential Fast-Acting Antidepressant?

Jianjun Yang, Wenyuan Li, Zhiqiang Zhou, Chun Yang

J Neurol Sci. 2012 Apr 15;315(1-2):180; author reply 181-2.

PMID: 22169632

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1Metabolism and Pharmacokinetics of JM6 in Mice: JM6 Is Not a Prodrug for Ro-61-8048

Maria G Beconi, Dawn Yates, Kathryn Lyons, Kim Matthews, Steve Clifton, Tania Mead, Michael Prime, Dirk Winkler, Catherine O'Connell, Daryl Walter, Leticia Toledo-Sherman, Ignacio Munoz-Sanjuan, Celia Dominguez

Drug Metab Dispos. 2012 Dec;40(12):2297-306.

PMID: 22942319

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1The Kynurenine 3-hydroxylase Inhibitor Ro 61-8048 Improves Dystonia in a Genetic Model of Paroxysmal Dyskinesia

Angelika Richter, Melanie Hamann

Eur J Pharmacol. 2003 Sep 30;478(1):47-52.

PMID: 14555184

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