CAS 78628-80-5 Terbinafine Hydrochloride - Analytical Products / Alfa Chemistry

CAT	APS78628805
CAS	78628-80-5
Structure
MDL Number	MFCD00145430
Synonyms	Bramizil, 1-Naphthalenemethanamine, N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-, hydrochloride, (E)-, Muzonal, Terbina, Bramazil, 1-Naphthalenemethanamine, N-[(2E)-6,6-dimethyl-2-hepten-4-ynyl]-N-methyl-, hydrochloride (9CI), Lamisil,Terbinafine Hydrochloride
IUPAC Name	(E)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine;hydrochloride
Molecular Weight	327.89
Molecular Formula	C21H25N.ClH
Canonical SMILES	Cl.CN(C\C=C\C#CC(C)(C)C)Cc1cccc2ccccc12
InChI	InChI=1S/C21H25N.ClH/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19
InChI Key	BWMISRWJRUSYEX-SZKNIZGXSA-N

Accurate Mass	327.1754
Format	Neat

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CAT	Size	Shipping	Storage Conditions	Description	Price
APS78628805-1	100MG	Room Temperature		Subcategory: British Pharmacopoeia; API Family: Matrix - API Family See respective official monograph(s); Product Type: API	Inquiry
APS78628805-2	100MG	Room Temperature	+20°C	Subcategory: Pharmaceutical and veterinary compounds and metabolites	Inquiry
APS78628805-3	10MG	Room Temperature	2-8°C Fridge/Coldroom	Subcategory: European Pharmacopoeia (Ph. Eur.); API Family: Matrix - API Family See respective official monograph(s); Product Type: API	Inquiry
APS78628805-4	250MG	Room Temperature	+5°C	Subcategory: Antimycotics, API standards, Mikromol; API Family: Matrix - API Family Terbinafine Hydrochloride; Product Type:	Inquiry

Case Study

Terbinafine Hydrochloride Used for the Preparation of pH-Responsive Composite Hydrogels for Hydrophobic Drug Delivery

Liu, Chengzhi, et al. International Journal of Biological Macromolecules (2025): 140431.

Terbinafine Hydrochloride (TFH), a poorly water-soluble antifungal agent, presents significant formulation challenges in hydrogel-based drug delivery systems due to its hydrophobic nature. To overcome this limitation, a novel composite hydrogel was developed incorporating TFH/hydroxypropyl-β-cyclodextrin inclusion complexes (TFH/HP-β-CD ICs) into a Schiff base hydrogel matrix composed of octenyl succinic anhydride-modified chitosan (OSA-CS) and sodium alginate (OIA).
The inclusion complex, prepared via solution stirring and freeze-drying, significantly enhanced TFH solubility in water to 32.13 mg/mL. Various parameters, including molar ratios (1:0.5 to 1:2.5), stirring speeds (100-500 rpm), and temperatures (20-50 °C), were systematically optimized to maximize encapsulation efficiency. Ethanol removal by rotary evaporation and filtration through 0.45 µm membranes ensured purification prior to lyophilization.
The resulting TFH GEL demonstrated excellent encapsulation stability, with no detectable drug leakage, and exhibited pH-responsive drug release behavior under acidic conditions-ideal for targeted antifungal therapy in acidic infection microenvironments. This study highlights TFH's potential in advanced hydrogel formulations and offers a viable platform for the controlled delivery of other hydrophobic therapeutics.

Terbinafine Hydrochloride Used for the Preparation of Nanofibrous Buccal Films to Enhance Local Antifungal Therapy

Szabó, Péter, et al. Journal of Pharmaceutical and Biomedical Analysis 131 (2016): 156-159.

Terbinafine Hydrochloride (TFH), a widely used antifungal agent, suffers from poor aqueous solubility, limiting its local therapeutic efficacy. To address this, TFH was incorporated into nanofibrous buccal films via electrospinning, using poly(vinyl alcohol) (PVA) and chitosan as the polymeric matrix to improve mucoadhesion and bioavailability.
A TFH stock solution was prepared by dispersing 0.20 g of the drug in polysorbate 60 under mild heating, followed by partial dilution in 2% v/v acetic acid to achieve a clear, solubilized system. This solution was blended with PVA and chitosan, then homogenized at 80 °C for 2 hours to form a gel suitable for electrospinning.
The optimized electrospinning parameters included a flow rate of 1.0 mL/h and an applied voltage of 25 kV. Fibers were collected on a grounded 625 cm² aluminum-covered surface at a 15 cm tip-to-collector distance. The resulting TFH-loaded nanofibers demonstrated uniform morphology and structural integrity.
This formulation significantly enhanced the dissolution rate of TFH and ensured localized drug release with improved mucosal retention. The approach offers a promising platform for the development of effective, patient-compliant antifungal therapies for oral candidiasis and related mucosal infections.

Terbinafine Hydrochloride Used for the Preparation of Antifungal PDMS/Organo-Montmorillonite Nanocomposite Films

Meng, Na, et al. Applied clay science 46.2 (2009): 136-140.

Terbinafine Hydrochloride (Ter-HCl), a potent antifungal compound, was successfully applied in the preparation of poly(dimethylsiloxane) (PDMS)/organo-montmorillonite (OMMT) nanocomposite films to endow silicone materials with intrinsic antifungal properties. The nanocomposite system was developed via solution intercalation, utilizing organo-modified montmorillonite as a functional nanofiller.
Organo-montmorillonite (OMMT) was synthesized through ion exchange between Na⁺-montmorillonite and Ter-HCl. Specifically, 1 g of Na⁺-MMT was dispersed in water, followed by addition of 2 g of Ter-HCl dissolved in ethanol. The mixture was vigorously stirred at 80 °C for 3 hours to facilitate efficient intercalation. The resulting Ter-HCl/MMT hybrid was purified by centrifugation, washed, and vacuum-dried at 80 °C to obtain the OMMT powder.
Subsequently, the antifungal OMMT was incorporated into a PDMS matrix. The dispersion was vortexed for 3 hours, followed by addition of tetraethyl orthosilicate (TEOS) as a crosslinker. Dibutyltin dilaurate was used as the catalyst. After thorough mixing, the samples were vacuum-cured at room temperature to eliminate volatile by-products. The resulting films were stable and uniform, with sustained antifungal functionality attributed to the embedded Ter-HCl.
This study demonstrates the utility of Terbinafine Hydrochloride in fabricating functional polymer nanocomposites for biomedical and antifungal surface applications.