TVB-3166

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For Research Use Only | Not For Clinical Use
CATAP1533438833
CAS1533438-83-3
Molecular Weight384.47
Description≥98% (HPLC)
SolubilityDMSO: 5 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C

1Anticancer Properties of the Fatty Acid Synthase Inhibitor TVB-3166 on Oral Squamous Cell Carcinoma Cell Lines

Iara Gonçalves de Aquino, Débora Campanella Bastos, Florence Juana Maria Cuadra-Zelaya, Isadora Ferrari Teixeira, Tuula Salo, Ricardo Della Coletta, Edgard Graner

Arch Oral Biol. 2020 May;113:104707.

PMID: 32197133

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1Direct Inhibition of Cellular Fatty Acid Synthase Impairs Replication of Respiratory Syncytial Virus and Other Respiratory Viruses

Yamini M Ohol, Zhaoti Wang, George Kemble, Gregory Duke

PLoS One. 2015 Dec 11;10(12):e0144648.

PMID: 26659560

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1Down-regulation of PKM2 Decreases FASN Expression in Bladder Cancer Cells Through AKT/mTOR/SREBP-1c Axis

Ting Tao, Qiongli Su, Simeng Xu, Jun Deng, Sichun Zhou, Yu Zhuang, Yanjun Huang, Caimei He, Shanping He, Mei Peng, Berthold Hocher, Xiaoping Yang

J Cell Physiol. 2019 Mar;234(3):3088-3104.

PMID: 30221356

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1FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models Through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Expression

Timothy S Heuer, Richard Ventura, Kasia Mordec, Julie Lai, Marina Fridlib, Douglas Buckley, George Kemble

EBioMedicine. 2017 Feb;16:51-62.

PMID: 28159572

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1Inhibition of De Novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression

Richard Ventura, Kasia Mordec, Joanna Waszczuk, Zhaoti Wang, Julie Lai, Marina Fridlib, Douglas Buckley, George Kemble, Timothy S Heuer

EBioMedicine. 2015 Jul 2;2(8):808-24.

PMID: 26425687

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