VH298

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For Research Use Only | Not For Clinical Use
CATIAR4245531
Molecular Weight523.65
Description≥98% (HPLC)
SolubilityDMSO: 10 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C

1Potent and Selective Chemical Probe of Hypoxic Signalling Downstream of HIF-α Hydroxylation via VHL Inhibition

Julianty Frost, Carles Galdeano, Pedro Soares, Morgan S Gadd, Katarzyna M Grzes, Lucy Ellis, Ola Epemolu, Satoko Shimamura, Marcus Bantscheff, Paola Grandi, Kevin D Read, Doreen A Cantrell, Sonia Rocha, etc.

Nat Commun. 2016 Nov 4;7:13312.

PMID: 27811928

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1Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader

Hannah Tovell, Andrea Testa, Chiara Maniaci, Houjiang Zhou, Alan R Prescott, Thomas Macartney, Alessio Ciulli, Dario R Alessi

ACS Chem Biol. 2019 May 17;14(5):882-892.

PMID: 30978004

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1RNA-seq Analysis of PHD and VHL Inhibitors Reveals Differences and Similarities to the Hypoxia Response

Julianty Frost, Alessio Ciulli, Sonia Rocha

Wellcome Open Res. 2019 Jan 29;4:17.

PMID: 30801039

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1Von Hippel-Lindau (VHL) Protein Antagonist VH298 Improves Wound Healing in Streptozotocin-Induced Hyperglycaemic Rats by Activating Hypoxia-Inducible Factor- (HIF-) 1 Signalling

Shuo Qiu, Yachao Jia, Yunchu Sun, Pei Han, Jia Xu, Gen Wen, Yimin Chai

J Diabetes Res. 2019 Feb 17;2019:1897174.

PMID: 30911550

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1Von Hippel-Lindau (VHL) Protein Antagonist, VH298, Promotes Functional Activities of Tendon-Derived Stem Cells and Accelerates Healing of Entheses in Rats by Inhibiting Ubiquitination of hydroxy-HIF-1α

Shuo Qiu, Yachao Jia, Jin Tang, Xuanzhe Liu, Hai Hu, Tianyi Wu, Yimin Chai

Biochem Biophys Res Commun. 2018 Nov 10;505(4):1063-1069.

PMID: 30314704

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