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For Research Use Only | Not For Clinical Use
MDL NumberMFCD30182240
Molecular Weight382.50
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear
Assay≥98% (HPLC)
Coloroff-white to blue-gray
Size5MG, 25MG
Storage Conditions2-8°C

1KCC2 Antagonism Increases Neuronal Network Excitability but Disrupts Ictogenesis in Vitro

Li-Yuan Chen, Maxime Lévesque, Massimo Avoli

J Neurophysiol. 2019 Sep 1;122(3):1163-1173.

PMID: 31339790

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1KCC2-Mediated Cl - Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice

Inkeri Spoljaric, Albert Spoljaric, Martina Mavrovic, Patricia Seja, Martin Puskarjov, Kai Kaila

Cell Rep. 2019 Jan 29;26(5):1073-1081.e3.

PMID: 30699338

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1Molecular Architecture of Potassium Chloride Co-Transporter KCC2

Morgane Agez, Patrick Schultz, Igor Medina, David J Baker, Matthew P Burnham, Ross A Cardarelli, Leslie C Conway, Kelly Garnier, Stefan Geschwindner, Anders Gunnarsson, Eileen J McCall, Alexandre Frechard, etc.

Sci Rep. 2017 Nov 28;7(1):16452.

PMID: 29184062

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1Selective Inhibition of KCC2 Leads to Hyperexcitability and Epileptiform Discharges in Hippocampal Slices and in Vivo

Sudhir Sivakumaran, Ross A Cardarelli, Jamie Maguire, Matt R Kelley, Liliya Silayeva, Danielle H Morrow, Jayanta Mukherjee, Yvonne E Moore, Robert J Mather, Mark E Duggan, Nicholas J Brandon, John Dunlop, etc.

J Neurosci. 2015 May 27;35(21):8291-6.

PMID: 26019342

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1Use of chemical probes to explore the toxicological potential of the K +/Cl - cotransporter (KCC) as a novel insecticide target to control the primary vector of dengue and Zika virus, Aedes aegypti

Francis J Prael 3rd, Rui Chen, Zhilin Li, Carson W Reed, Craig W Lindsley, C David Weaver, Daniel R Swale

Pestic Biochem Physiol. 2018 Oct;151:10-17.

PMID: 30704707

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