VX-745

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For Research Use Only | Not For Clinical Use

CAT	AP209410468
CAS	209410-46-8
Structure
MDL Number	MFCD09834070
Molecular Weight	436.26
InChI Key	VEPKQEUBKLEPRA-UHFFFAOYSA-N

Description	≥98% (HPLC)
Solubility	DMSO: 10 mg/mL, clear
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	−20°C

1Activating β-catenin/Pax6 Axis Negatively Regulates Osteoclastogenesis by Selectively Inhibiting Phosphorylation of p38/MAPK

Zhiwei Jie, Shuying Shen, Xiangde Zhao, Wenbin Xu, Xuyang Zhang, Bao Huang, Pan Tang, An Qin, Shunwu Fan, Ziang Xie

FASEB J. 2019 Mar;33(3):4236-4247.

PMID: 30526042

1Gram-scale Synthesis of the p38α MAPK-inhibitor VX-745 for Preclinical Studies Into Werner Syndrome

Mark C Bagley, Terence Davis, Matthew C Dix, Vincenzo Fusillo, Morgane Pigeaux, Michal J Rokicki, David Kipling

Future Med Chem. 2010 Sep;2(9):1417-27.

PMID: 21426137

1Rapid Synthesis of VX-745: p38 MAP Kinase Inhibition in Werner Syndrome Cells

Mark C Bagley, Terence Davis, Matthew C Dix, Michal J Rokicki, David Kipling

Bioorg Med Chem Lett. 2007 Sep 15;17(18):5107-10.

PMID: 17659871

1The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor

John P Duffy, Edmund M Harrington, Francesco G Salituro, John E Cochran, Jeremy Green, Huai Gao, Guy W Bemis, Ghotas Evindar, Vincent P Galullo, Pamella J Ford, Ursula A Germann, Keith P Wilson, Steven F Bellon, etc.

ACS Med Chem Lett. 2011 Jul 28;2(10):758-63.

PMID: 24900264

1VX-745. Vertex Pharmaceuticals

J J Haddad

Curr Opin Investig Drugs. 2001 Aug;2(8):1070-6.

PMID: 11892915

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