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2,5-hexanedione-induced Testicular Injury

2,5-hexanedione-induced Testicular Injury

Kim Boekelheide, Shawna L Fleming, Theresa Allio, Michelle E Embree-Ku, Susan J Hall, Kamin J Johnson, Eun Ji Kwon, Sutchin R Patel, Reza J Rasoulpour, Heidi A Schoenfeld, Stephanie Thompson

Annu Rev Pharmacol Toxicol. 2003;43:125-47.

PMID: 12471174

Abstract:

Now in its third decade of mechanistic investigation, testicular injury caused by 2,5-hexanedione (2,5-HD) exposure is a well-studied model with a rich database. The development of this model reflects the larger changes that have moved biology from a branch of chemistry into the molecular age. Critically examined in this review is the proposed mechanism for 2,5-HD-induced testicular injury in which germ cell maturation is disrupted owing to alterations in Sertoli cell microtubule-mediated functions. The goal is to evaluate the technical and conceptual approaches used to assess 2,5-HD-induced testicular injury, to highlight unanswered questions, and to identify fruitful avenues of future research.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP110134	2,5-Hexanedione		110-13-4	Price

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