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2-Hydroxysaclofen, a Potent GABAB Receptor Antagonist, Stimulates Luteinizing Hormone Secretion in Female Rats

T Akema, F Kimura

Brain Res. 1991 Apr 12;546(1):143-5.

PMID: 1649666

Abstract:

An intraventricular injection of a potent GABAB receptor antagonist, 2-hydroxysaclofen, elicited luteinizing hormone (LH) secretion in a dose-dependent manner under the negative feedback condition in ovariectomized estrogen-primed rats. Significant reduction of the effect of 2-hydroxysaclofen by baclofen, a selective GABAB agonist, suggested that the antagonist stimulated LH secretion through interaction with the GABAB receptor. These results provide evidence that the endogenous GABA acting at the GABAB receptor plays a physiological role in controlling basal LH secretion.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP117354640 2-Hydroxysaclofen 2-Hydroxysaclofen 117354-64-0 Price
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