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A Biomimetic Strategy to Access the Silybins: Total Synthesis of (-)-Isosilybin A

Benjamin R McDonald, Antoinette E Nibbs, Karl A Scheidt

Org Lett. 2015 Jan 2;17(1):98-101.

PMID: 25517432

Abstract:

We report the first asymmetric, total synthesis of (-)-isosilybin A. A late-stage catalytic biomimetic cyclization of a highly functionalized chalcone is employed to form the characteristic benzopyranone ring. A robust and flexible approach to this chalcone provides an entry to the preparation of the entire isomeric family of silybin natural products.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP142796212 Isosilybin A Isosilybin A 142796-21-2 Price
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