0

A Biomimetic Strategy to Access the Silybins: Total Synthesis of (-)-Isosilybin A

Benjamin R McDonald, Antoinette E Nibbs, Karl A Scheidt

Org Lett. 2015 Jan 2;17(1):98-101.

PMID: 25517432

Abstract:

We report the first asymmetric, total synthesis of (-)-isosilybin A. A late-stage catalytic biomimetic cyclization of a highly functionalized chalcone is employed to form the characteristic benzopyranone ring. A robust and flexible approach to this chalcone provides an entry to the preparation of the entire isomeric family of silybin natural products.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP142796212 Isosilybin A Isosilybin A 142796-21-2 Price
qrcode

We use cookies to understand how you use our site and to improve the overall user experience. This includes personalizing content and advertising. Read our Privacy Policy

Accept Cookies
x