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A Recombinant anti-erbB2, scFv-Fc-IL-2 Fusion Protein Retains Antigen Specificity and Cytokine Function

A Recombinant anti-erbB2, scFv-Fc-IL-2 Fusion Protein Retains Antigen Specificity and Cytokine Function

Ming Shi, Zhigang Xie, Jiannan Feng, Yingxun Sun, Ming Yu, Beifen Shen, Ning Guo

Biotechnol Lett. 2003 May;25(10):815-9.

PMID: 12882013

Abstract:

Elevated erbB2 expression is detected in many in situ and invasive human ductal carcinomas. Anti-erbB2 antibody directed at the extracellular domain of erbB2 can result in an antitumor response in some patients with tumors overexpressing erbB2 oncoprotein. By combining interleukin 2 (IL-2) activities with a tumor specific antibody, immunotherapy of tumors might be more effective in the future. In this study, a fusion protein consisting of erbB2 single chain antibody (scFv), Fc fragment of human IgG1 and IL-2 was constructed. The molecular weight of fusion proteins is 66 kDa, only one third of whole antibody-IL-2 fusion protein or 44% whole Ig molecule. The fusion proteins retained the activities of both antigen binding and IL-2. The scFv-Fc-IL-2 fusion protein may have advantages over whole antibody-IL-2 fusion proteins, such as smaller molecule, better activity of penetration, more favorable pharmacokinetic properties.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413378	IL-2 (human): FC (human)			Price

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