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A Review of Methotrexate-Associated Hepatotoxicity

Roopjeet K Bath, Navkiran K Brar, Faripour A Forouhar, George Y Wu

J Dig Dis. 2014 Oct;15(10):517-24.

PMID: 25139707

Abstract:

Methotrexate is effective not only in treating psoriasis and rheumatoid arthritis but also various other disorders. The use of methotrexate has been somewhat limited by concerns regarding its adverse effects, including its potential for hepatotoxicity. The purpose of this article is to provide an overview of methotrexate-associated hepatotoxicity, including risk factors, pathogenesis and recommendations for monitoring it by US, UK and European guidelines, as well as providing a brief overview of its mechanism of action and of high-dose methotrexate.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP59052-B Methotrexate Methotrexate 59-05-2 Price
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