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A Thalidomide Analogue With in Vitro Antiproliferative, Antimitotic, and Microtubule-Stabilizing Activities

Pui-Kai Li, Bulbul Pandit, Dan L Sackett, Zhigen Hu, Jennifer Zink, Jiandong Zhi, Dena Freeman, Robert W Robey, Karl Werbovetz, Andrew Lewis, Chenglong Li

Mol Cancer Ther. 2006 Feb;5(2):450-6.

PMID: 16505120

Abstract:

We discovered a thalidomide analogue [5-hydroxy-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione (5HPP-33)] with antiproliferative activity against nine cancer cell lines in vitro. Flow cytometric analyses showed that the compound caused G2-M arrest, which occurred mainly at the mitotic phase. In addition, immunofluorescence microscopy and in vitro tubulin polymerization studies showed that 5HPP-33 has antimicrotubule activity with a paclitaxel-like mode of action. It is effective against four different paclitaxel-resistant cell lines. Thus, 5HPP-33 represents a potential antitumor agent.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP105624860 5HPP-33 5HPP-33 105624-86-0 Price
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