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ACS Chemical Neuroscience Molecule Spotlight on Begacestat (GSI-953)

Corey R Hopkins

ACS Chem Neurosci. 2012 Jan 18;3(1):3-4.

PMID: 22860177

Abstract:

A "second generation" γ-secretase, Begacestat (GSI-953), which is more selective against Notch-signaling, has shown promise in recent Phase I clinical trials. Begacestat, a novel, 2,5-disubsitituted thiophene sulfonamide from Wyeth (now Pfizer) is under evaluation for the treatment of Alzheimer's disease.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP769169279 Begacestat Begacestat 769169-27-9 Price
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