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Activation of 5-HT3 Receptor by 1-phenylbiguanide Increases Dopamine Release in the Rat Nucleus Accumbens

Activation of 5-HT3 Receptor by 1-phenylbiguanide Increases Dopamine Release in the Rat Nucleus Accumbens

J P Chen, H M van Praag, E L Gardner

Brain Res. 1991 Mar 15;543(2):354-7.

PMID: 1711914

Abstract:

The serotonin-3 (5-HT3) agonist 1-phenylbiguanide (0.1-1.0 mM in perfusate) caused a robust, dose-dependent enhancement of extracellular dopamine content in nucleus accumbens as measured by in vivo microdialysis. This action was antagonized by co-perfusion of the 5-HT3 antagonists zacopride and GR38032F (1 mM in perfusate). Similar effects were observed in 5-HT-denervated rats. These findings suggest that there is a potent modulation of dopamine (DA) release in the nucleus accumbens mediated via 5-HT3 receptors, which appear to be located presynaptically on DA terminals of the mesolimbic DA pathway.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP102023	1-Phenylbiguanide		102-02-3	Price

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