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Adenosine A(2A) Receptor Antagonists and Parkinson's Disease

Adenosine A(2A) Receptor Antagonists and Parkinson's Disease

Brian C Shook, Paul F Jackson

ACS Chem Neurosci. 2011 Oct 19;2(10):555-67.

PMID: 22860156

Abstract:

This Review summarizes and updates the work on adenosine A(2A) receptor antagonists for Parkinson's disease from 2006 to the present. There have been numerous publications, patent applications, and press releases within this time frame that highlight new medicinal chemistry approaches to this attractive and promising target to treat Parkinson's disease. The Review is broken down by scaffold type and will discuss the efforts to optimize particular scaffolds for activity, pharmacokinetics, and other drug discovery parameters. The majority of approaches focus on preparing selective A(2A) antagonists, but a few approaches to dual A(2A)/A(1) antagonists will also be highlighted. The in vivo profiles of compounds will be highlighted and discussed to compare activities across different chemical series. A clinical report and update will be given on compounds that have entered clinical trials.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4249383	Adenosine A 2A/A₁ Receptor Antagonist			Price

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