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Antioxidant, EUK-8, Prevents Murine Dilated Cardiomyopathy

Antioxidant, EUK-8, Prevents Murine Dilated Cardiomyopathy

Satoru Kawakami, Akina Matsuda, Tadahiro Sunagawa, Yoshihiro Noda, Takao Kaneko, Shoichi Tahara, Yoshimi Hiraumi, Souichi Adachi, Hiromitsu Matsui, Katsuyuki Ando, Toshiro Fujita, Naoki Maruyama, Takuji Shirasawa, etc.

Circ J. 2009 Nov;73(11):2125-34.

PMID: 19749480

Abstract:

Background:
Mice lacking manganese-superoxide dismutase (Mn-SOD) activity exhibit the typical pathology of dilated cardiomyopathy (DCM). In the present study, presymptomatic and symptomatic mutant mice were treated with the SOD/catalase mimetic, EUK-8.
Methods and results:
Presymptomatic heart/muscle-specific Mn-SOD-deficient mice (H/M-Sod2(-/-)) were treated with EUK-8 (30 mg x kg(-1) . day(-1)) for 4 weeks, and then cardiac function and the reactive oxygen species (ROS) production in their heart mitochondria were assessed. EUK-8 treatment suppressed the progression of cardiac dysfunction and diminished ROS production and oxidative damage. Furthermore, EUK-8 treatment effectively reversed the cardiac dilatation and dysfunction observed in symptomatic H/M-Sod2(-/-) mice. Interestingly, EUK-8 treatment repaired a molecular defect in connexin43.
Conclusions:
EUK-8 treatment can prevent and cure murine DCM, so SOD/catalase mimetic treatment is proposed as a potential therapy for DCM.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP53177121	EUK-8		53177-12-1	Price

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