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Arachidonyl Trifluoromethyl Ketone Induces Lipid Body Formation in Leukocytes

Arachidonyl Trifluoromethyl Ketone Induces Lipid Body Formation in Leukocytes

P T Bozza, P F Weller

Prostaglandins Leukot Essent Fatty Acids. Apr-May 2001;64(4-5):227-30.

PMID: 11418016

Abstract:

Leukocyte lipid bodies, abundant in cells associated with inflammation, can be induced to form in response to stimuli that include cis -unsaturated, but not saturated, fatty acids. Arachidonyl trifluoromethyl ketone (AACOCF(3)), a non-esterifiable arachidonate analog and an inhibitor of cytosolic phospholipase A(2)enzymes (PLA(2)), dose-dependently (0-20 microM) stimulated neutrophil lipid body formation, but this stimulation was not attributable to PLA(2)inhibition. Palmitoyl trifluoromethyl ketone, also a PLA(2)inhibitor, failed to stimulate lipid body formation, like palmitic acid itself, and did not inhibit stimulated lipid body formation. Moreover, aspirin, indomethacin and ibuprofen, which inhibit cis -unsaturated fatty acid-induced lipid body formation, inhibited AACOCF(3)-induced lipid body formation. Lipid body induction with AACOCF(3)reflected its structural basis as a cis -unsaturated fatty acid analog. These results indicate that cytosolic PLA(2)enzymes are not active in lipid body induction and cis -fatty acid stimulation of lipid body formation does not require esterification of cis -fatty acids into glycerolipids.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP149301791	Arachidonyl trifluoromethyl ketone		149301-79-1	Price

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