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Bactericidal and Anti-biofilm Activity of the Retinoid Compound CD437 Against

Bactericidal and Anti-biofilm Activity of the Retinoid Compound CD437 Against

Fang Tan, Pengfei She, Linying Zhou, Yiqing Liu, Lihua Chen, Zhen Luo, Yong Wu

Front Microbiol. 2019 Oct 9;10:2301.

PMID: 31649642

Abstract:

Enterococcus faecalis (E. faecalis), a biofilm-forming pathogen, causes nosocomial infections. In recent years, drug resistance by enterococci has become increasingly severe due to widespread antibiotic abuse. Therefore, novel antibacterial agents are urgently needed. In this study, the synthetic retinoid compound CD437 was found to have potent bactericidal effect on E. faecalis. In addition, CD437 exhibited synergistic effects when administered in combination with gentamicin and additive effects when combined with ceftriaxone sodium. CD437 also inhibited biofilm formation by E. faecalis and exerted bactericidal effect on mature biofilm. Moreover, CD437 exhibited antibacterial and anti-biofilm effects against Staphylococcus. No bactericidal action of CD437 was observed against the gram-negative bacillus, but Pseudomonas aeruginosa biofilm extracellular polymeric substances (EPS) matrix formation was reduced. Overall, these findings indicate that CD437 has the potential to be developed as a novel antibacterial drug.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP125316601	CD437		125316-60-1	Price

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