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Benzoyl Peroxide (BPO)-promoted Oxidative Trifluoromethylation of Tertiary Amines With Trimethyl(trifluoromethyl)silane

Lingling Chu, Feng-Ling Qing

Chem Commun (Camb). 2010 Sep 14;46(34):6285-7.

PMID: 20694243

Abstract:

The benzoyl peroxide (BPO)-promoted oxidative functionalization of tertiary amines under transition-metal-free reaction conditions was developed. Various 1-trifluoromethylated tetrahydroisoquinoline derivatives were prepared by employing this method. It constitutes the first example of direct trifluoromethylation of tertiary amines.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP81290202 Trimethyl(trifluoromethyl)silane Trimethyl(trifluoromethyl)silane 81290-20-2 Price
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