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Biocatalytic Total Synthesis of Ikarugamycin

Biocatalytic Total Synthesis of Ikarugamycin

Christian Greunke, Anna Glöckle, Janine Antosch, Tobias A M Gulder

Angew Chem Int Ed Engl. 2017 Apr 3;56(15):4351-4355.

PMID: 28128495

Abstract:

Nature provides an inexhaustible diversity of small organic molecules with beautiful molecular architectures that have strong and selective inhibitory activities. However, this tremendous biomedical potential often remains inaccessible, as the structural complexity of natural products can render their synthetic preparation extremely challenging. This problem is addressable by harnessing the biocatalytic procedures evolved by nature. In this work, we present an enzymatic total synthesis of ikarugamycin. The use of an iterative PKS/NRPS machinery and two reductases has allowed the construction of 15 carbon-carbon and 2 carbon-nitrogen bonds in a biocatalytic one-pot reaction. By scaling-up this method we demonstrate the applicability of biocatalytic approaches for the ex vivo synthesis of complex natural products.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP36531789	Ikarugamycin		36531-78-9	Price

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