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Blockade of JAK2 by Tyrphostin AG-490 Inhibits Antigen-Induced Eosinophil Recruitment Into the Mouse Airways

Blockade of JAK2 by Tyrphostin AG-490 Inhibits Antigen-Induced Eosinophil Recruitment Into the Mouse Airways

K Kumano, A Nakao, H Nakajima, S Miike, K Kurasawa, Y Saito, I Iwamoto

Biochem Biophys Res Commun. 2000 Apr 2;270(1):209-14.

PMID: 10733929

Abstract:

We studied the effect of tyrphostin AG-490, a specific Janus kinase 2 (JAK2) inhibitor, on antigen-induced eosinophil recruitment into the airways of sensitized mice and on IL-5-induced chemokinesis and adhesiveness of eosinophils. The in vivo administration of AG-490 prevented antigen-induced eosinophil infiltration in the airways of sensitized mice in a dose-dependent manner. However, the administration of AG-490 did not affect antigen-induced IL-5 production in the airways nor in vitro antigen-induced IL-5 production and T cell proliferation of spleen cells. Furthermore, AG-490 inhibited IL-5-induced chemokinesis and beta1-integrin adhesiveness of eosinophils in vitro. Because antigen-induced eosinophil recruitment into the airways is mediated by IL-5, these results indicate that JAK2 activation is critical for antigen-induced, IL-5-dependent mobilization of eosinophils into the tissue.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP133550308-B	Tyrphostin AG 490		133550-30-8	Price

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