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Calphostins (UCN-1028), Novel and Specific Inhibitors of Protein Kinase C. I. Fermentation, Isolation, Physico-Chemical Properties and Biological Activities

Calphostins (UCN-1028), Novel and Specific Inhibitors of Protein Kinase C. I. Fermentation, Isolation, Physico-Chemical Properties and Biological Activities

E Kobayashi, K Ando, H Nakano, T Iida, H Ohno, M Morimoto, T Tamaoki

J Antibiot (Tokyo). 1989 Oct;42(10):1470-4.

PMID: 2478514

Abstract:

A novel complex of calphostin (UCN-1028), which specifically inhibits protein kinase C (PKC) has been isolated from the culture broth of a fungi Cladosporium cladosporioides. Purification of individual components was carried out by silica gel, non-porus resin Diaion HP-20SS and Sephadex LH-20 chromatography, leading to isolation of five closely related components. A, B, C, D and I. Calphostins showed cytotoxic activities against various tumor cells, and these cytotoxicities were proportional to their inhibitory activities against PKC.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP121263192-A	Calphostin C from Cladosporium cladosporioides		121263-19-2	Price

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