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[CARDIOPROTFETIVE EFECTS OF NECROSTATIN-7 IN THE RAT MODEL OF PERMANENT CORONARY OCCLUSION]

Yu V Dmitriev, A A Karpov, A V Dracheva, S M Minasian, S G Chefu, L V Vasina, E A Demchenko, I M M Galagudza

Ross Fiziol Zh Im I M Sechenova. 2015 Apr;101(4):408-14.

PMID: 26336739

Abstract:

The cardioprotective effects of necroptosis inhibitor necrostatin-7 were studied in the rat model of permanent coronary occlusion. It was found that intraperitoneal injection of necrostatin-7 at a dose of 14.5 mg/kg 60 minutes prior to permanent left coronary artery occlusion reduced the amount of scar tissue and scar length in the left ventricle on the 21st day after surgery. In addition, pretreatment with necrostatin-7 resulted in decreased plasma level of N-terminal pro-brain natriuretic peptide, which points to the improvement in left ventricular function.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP351062083 Necrostatin-7 Necrostatin-7 351062-08-3 Price
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