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λ-Carrageenan Improves the Antitumor Effect of Dendritic Cellbased Vaccine

λ-Carrageenan Improves the Antitumor Effect of Dendritic Cellbased Vaccine

Jinyao Li, Adila Aipire, Jinyu Li, Hongge Zhu, Yanping Wang, Wenjia Guo, Xiaoqin Li, Jia Yang, Chunling Liu

Oncotarget. 2017 May 2;8(18):29996-30007.

PMID: 28404904

Abstract:

In this study, we investigated the effect of λ-carrageenan on the maturation and function of dendritic cells (DCs) and its adjuvant effect on DC-based vaccine. We found that λ-carrageenan dose-dependently decreased the endocytosis of DCs, promoted DC maturation and increased cytokine production through TLR4 mediated signaling pathway. λ-carrageenan treatment also enhanced the ability of DCs in the stimulating allogenic splenocyte proliferation. In TC-1 tumor mouse model, HPV peptides pulsed λ-carrageenan-DC (HPV-CGN-DC) significantly inhibited tumor growth compared with control group. The frequencies of CD4+ and CD8+ T cells in spleens of tumor mice and their activation status were significantly increased in HPV-CGN-DC group, but the frequencies of natural regulatory T cells and CD11b+Gr-1+ cells were significantly decreased. Further, HPV-CGN-DC induced strong CD8+ T cell responses, which are negatively correlated with tumor volumes. The results suggested that λ-carrageenan promoted DC maturation through TLR4 signaling pathway and could be used as the adjuvant in DC-based vaccines.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9064577	λ-Carrageenan		9064-57-7	Price

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