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CB 1954 (2,4-dinitro-5-aziridinyl Benzamide) Becomes a DNA Interstrand Crosslinking Agent in Walker Tumour Cells

J J Roberts, F Friedlos, R J Knox

Biochem Biophys Res Commun. 1986 Nov 14;140(3):1073-8.

PMID: 3778483

Abstract:

Walker tumour cells were shown to be uniquely sensitive to CB 1954 when compared with other cells in vitro. CB 1954 forms DNA-DNA interstrand crosslinks in a time-dependent manner in Walker tumour but not Chinese hamster cells. The absence of interstrand crosslinks in hamster cells was not due to a lack of uptake of drug but rather to a failure to convert (probably by bioreduction) CB 1954 to the required reactive difunctional intermediate.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP21919051 CB 1954 CB 1954 21919-05-1 Price
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