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Cisplatin-Induced Ototoxicity: Updates on Molecular Targets

Cisplatin-Induced Ototoxicity: Updates on Molecular Targets

Erica Gentilin, Edi Simoni, Mariarita Candito, Diego Cazzador, Laura Astolfi

Trends Mol Med. 2019 Dec;25(12):1123-1132.

PMID: 31473143

Abstract:

Cis-diamminedichloridoplatinum (II) (cisplatin) is a chemotherapeutic drug currently prescribed for the treatment of many types of human cancer, but its use is associated with numerous adverse effects, one of which is ototoxicity. Cisplatin-induced hearing loss is mainly attributed to oxidative stress, but recent data suggest that inflammation could be the trigger event leading to inner ear cell death through endoplasmic reticulum (ER) stress, autophagy, necroptosis, and then intrinsic apoptosis. In this review, we look at the molecular targets of cisplatin, and the intracellular pathways underlying its ototoxicity. Special attention is devoted to signal transduction processes involving cisplatin that may promote the development of new strategies to prevent cisplatin-induced hearing loss, an adverse event with severe social impacts.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP15663271-A	Cisplatin		15663-27-1	Price

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